ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2011
Cytokine dysregulation in early- and late-term placentas from feline immunodeficiency virus (FIV)-infected cats.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Molecular Factors Involved in the Reproductive Morphophysiology of Female Domestic Cat (Animals : an open access journal from MDPI · 2023Review
- Combination Antiretroviral Therapy and Immunophenotype of Feline Immunodeficiency Virus.Viruses · 2023Article
- Infection with equine infectious anemia virus vaccine strain EIAVDLV121 causes no visible histopathological lesions in target organs in association with restricted viral replication and unique cytokine response.Veterinary immunology and immunopathology · 2016Article
- Aberrant placental immune parameters in the feline immunodeficiency virus (FIV)-infected cat suggest virus-induced changes in T cell function.Virology journal · 2013Article
- Role of the placenta in adverse perinatal outcomes among HIV-1 seropositive women.Journal of Nippon Medical School = Nippon Ika Daigaku zasshi · 2013Review
- Imbalance of placental regulatory T cell and Th17 cell population dynamics in the FIV-infected pregnant cat.Virology journal · 2012Article
- Immunomodulator expression in trophoblasts from the feline immunodeficiency virus (FIV)-infected cat.Virology journal · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
problemExperimental infection of cats with FIV-B-2542 produces high rates of fetal infection and reproductive failure. We hypothesized that dysregulation of placental cytokine expression occurs in FIV-infected queens, and aberrant expression potentiates inflammation and impacts pregnancy outcome. Our purpose was to quantify expression of representative pro-inflammatory cytokines (IL-6, IL-12p35, and IL-1β), IL-10 (anti-inflammatory), and the chemokine SDF-1α in early- and late-term placental tissues. METHOD OF STUDY: Real-time reverse transcriptase PCR was used to measure gene expression in placental tissues.
resultsIncreased expression of IL-6 and IL-12p35 and decreased expression of IL-10 occurred in FIV-infected tissues at early pregnancy; at late gestation, IL-6 expression increased and IL-1β and SDF-1α decreased. At late pregnancy, IL-6 expression positively correlated with FIV load. IL-12:IL-10 ratios were higher in infected tissues at early, but not late pregnancy. Fetal non-viability accompanied decreased IL-12p35 and SDF-1α expression at both stages and decreased IL-12:IL-10 ratio at late pregnancy.
conclusionFIV infection caused a pro-inflammatory placental microenvironment at early, but not late pregnancy.
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Registered trials
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