Evidence map›Paper›PMID 20824512›Full record

ReviewTheory in biosciences = Theorie in den Biowissenschaften2011

Seeing beyond the average cell: branching process models of cell proliferation, differentiation, and death during mouse brain development.

Hugh R MacMillan, Michael J McConnell

Abstract readReview
PubMed Publisher
In one paragraph

Review in Theory in biosciences = Theorie in den Biowissenschaften, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Emerging modelling methodologies in medicine and biology, Introduction to the special issue.Theory in biosciences = Theorie in den Biowissenschaften · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hugh R MacMillanDepartment of Mathematical Sciences, Clemson University, Clemson, SC 29634-0975, USA. hughrobertmacmillan@gmail.com
Michael J McConnell
Clemson University · USSalk Institute for Biological Studies · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We develop a family of branching process models to study cerebral cortical development at the level of individual neural stem and progenitor cells (NS/PCs) and the neurons they produce. Population-level data about "the average NS/PC" is incorporated as constraints for exploring (i) heterogeneity in the proliferative neural cell types and (ii) variability in daughter cell fate decision making. Preliminary studies demonstrate this variability, generate testable hypotheses about heterogeneity, and motivate new experiments moving forward.

Indexed as

Models, NeurologicalAnimalsCell DeathCell DifferentiationCell Growth ProcessesCerebral CortexMiceNeural Stem Cells

Identifiers

PMID20824512
OpenAlexW2052589547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.