ArticlePloS one2010
High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci.PloS one · 2012Pooled it
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.Aging cell · 2011Pooled it
- Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice.Journal of biomedical science · 2022Article
- Article
- Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
- Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival.Oncotarget · 2015Article
- Distinct patterns of sirtuin expression during progression of Alzheimer's disease.Neuromolecular medicine · 2014Article
- Genetics of healthy aging and longevity.Human genetics · 2013Review
- Article
- Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- UV, stress and aging.Dermato-endocrinology · 2012Article
- The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations.Immunity & ageing : I & A · 2012Article
- Integration of gene expression data with prior knowledge for network analysis and validation.BMC research notes · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundHuman lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the general population. METHODOLOGY/PRINCIPAL
findingsTo map the loci conferring a survival advantage, we performed the second genomewide linkage scan on human longevity and the first using a high-density marker panel of single nucleotide polymorphisms. By systematically testing a range of minimum age cutoffs in 279 families with multiple long-lived siblings, we identified a locus on chromosome 3p24-22 with a genomewide significant allele-sharing LOD score of 4.02 (empirical P = 0.037) and a locus on chromosome 9q31-34 with a highly suggestive LOD score of 3.89 (empirical P = 0.054). The empirical P value for the combined result was 0.002. A third novel locus with a LOD score of 4.05 on chromosome 12q24 was detected in a subset of the data, and we also obtained modest evidence for a previously reported interval on chromosome 4q22-25. CONCLUSIONS/SIGNIFICANCE: Our linkage data should facilitate the discovery of both common and rare variants that determine genetic variability in lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.