ArticlePloS one2010
Suppression of lung tumorigenesis by leucine zipper/EF hand-containing transmembrane-1.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Emerging role of LETM1/GRP78 axis in lung cancer.Cell death & disease · 2022Article
- Mitochondrial calcium exchange in physiology and disease.Physiological reviews · 2022Review
- The Novel Curcumin Derivative 1g Induces Mitochondrial and ER-Stress-Dependent Apoptosis in Colon Cancer Cells by Induction of ROS Production.Frontiers in oncology · 2021Article
- LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling.Frontiers in physiology · 2021Review
- LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.Journal of gastric cancer · 2020Article
- Characterisation of the developing heart in a pressure overloaded model utilising RNA sequencing to direct functional analysis.Journal of anatomy · 2020Article
- Article
- LETM1 is required for mitochondrial homeostasis and cellular viability (Review).Molecular medicine reports · 2019Review
- Knockdown of LETM1 inhibits proliferation and metastasis of human renal cell carcinoma cells.Oncology letters · 2018Article
- The mitochondrial membrane protein FgLetm1 regulates mitochondrial integrity, production of endogenous reactive oxygen species and mycotoxin biosynthesis in Fusarium graminearum.Molecular plant pathology · 2018Article
- Mitochondrial ribosomes in cancer.Seminars in cancer biology · 2017Review
- LETM1 overexpression is correlated with the clinical features and survival outcome of breast cancer.International journal of clinical and experimental pathology · 2015Article
- De Novo proteome analysis of genetically modified tumor cells by a metabolic labeling/azide-alkyne cycloaddition approach.Molecular & cellular proteomics : MCP · 2014Article
- High expression of leucine zipper-EF-hand containing transmembrane protein 1 predicts poor prognosis in head and neck squamous cell carcinoma.BioMed research international · 2014Article
- Co-delivery of LETM1 and CTMP synergistically inhibits tumor growth in H-ras12V liver cancer model mice.Cancer gene therapy · 2013Article
- Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.The Journal of general physiology · 2012Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundLeucine zipper/EF hand-containing transmembrane-1 (LETM1) encodes for the human homologue of yeast Mdm38p, which is a mitochondria-shaping protein of unclear function. However, a previous study demonstrated that LETM1 served as an anchor protein for complex formation between mitochondria and ribosome, and regulated mitochondrial biogenesis. METHODOLOGY/PRINCIPAL
findingsTherefore, we examine the possibility that LETM1 may function to regulate mitochondria and lung tumor growth. In this study, we addressed this question by studying in the effect of adenovirus-mediated LETM1 in the lung cancer cell and lung cancer model mice. To investigate the effects of adenovirus-LETM1 in vitro, we infected with adenovirus-LETM1 in A549 cells. Additionally, in vivo effects of LETM1 were evaluated on K-ras(LA1) mice, human non-small cell lung cancer model mice, by delivering the LETM1 via aerosol through nose-only inhalation system. The effects of LETM1 on lung cancer growth and AMPK related signals were evaluated. Adenovirus-mediated overexpression of LETM1 could induce destruction of mitochondria of lung cancer cells through depleting ATP and AMPK activation. Furthermore, adenoviral-LETM1 also altered Akt signaling and inhibited the cell cycle while facilitating apoptosis. Theses results demonstrated that adenovirus-LETM1 suppressed lung cancer cell growth in vitro and in vivo. CONCLUSIONS/SIGNIFICANCE: Adenovirus-mediated LETM1 may provide a useful target for designing lung tumor prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.