ArticlePloS one2010
Parent-of-origin effects in autism identified through genome-wide linkage analysis of 16,000 SNPs.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- UBE3A: The Role in Autism Spectrum Disorders (ASDs) and a Potential Candidate for Biomarker Studies and Designing Therapeutic Strategies.Diseases (Basel, Switzerland) · 2023Review
- Genetic Epidemiology of Complex Phenotypes.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Increased risk of ADHD in families with ASD.European child & adolescent psychiatry · 2019Article
- Sexual selection modulates genetic conflicts and patterns of genomic imprinting.Evolution; international journal of organic evolution · 2017Article
- Bio-collections in autism research.Molecular autism · 2017Review
- In Pursuit of New Imprinting Syndromes by Epimutation Screening in Idiopathic Neurodevelopmental Disorder Patients.BioMed research international · 2015Article
- The role of genomic imprinting in biology and disease: an expanding view.Nature reviews. Genetics · 2014Review
- Common DNA methylation alterations in multiple brain regions in autism.Molecular psychiatry · 2014Article
- Parental obesity and risk of autism spectrum disorder.Pediatrics · 2014Article
- Epigenetic epidemiology: promises for public health research.Environmental and molecular mutagenesis · 2014Review
- Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.Genes, brain, and behavior · 2014Article
- Epigenetic factors and autism spectrum disorders.Neuromolecular medicine · 2013Review
- Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder.Translational psychiatry · 2013Article
- DELISHUS: an efficient and exact algorithm for genome-wide detection of deletion polymorphism in autism.Bioinformatics (Oxford, England) · 2012Article
- Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.PloS one · 2012Article
- The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility.ILAR journal · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAutism is a common heritable neurodevelopmental disorder with complex etiology. Several genome-wide linkage and association scans have been carried out to identify regions harboring genes related to autism or autism spectrum disorders, with mixed results. Given the overlap in autism features with genetic abnormalities known to be associated with imprinting, one possible reason for lack of consistency would be the influence of parent-of-origin effects that may mask the ability to detect linkage and association. METHODS AND
findingsWe have performed a genome-wide linkage scan that accounts for potential parent-of-origin effects using 16,311 SNPs among families from the Autism Genetic Resource Exchange (AGRE) and the National Institute of Mental Health (NIMH) autism repository. We report parametric (GH, Genehunter) and allele-sharing linkage (Aspex) results using a broad spectrum disorder case definition. Paternal-origin genome-wide statistically significant linkage was observed on chromosomes 4 (LOD(GH) = 3.79, empirical p<0.005 and LOD(Aspex) = 2.96, p = 0.008), 15 (LOD(GH) = 3.09, empirical p<0.005 and LOD(Aspex) = 3.62, empirical p = 0.003) and 20 (LOD(GH) = 3.36, empirical p<0.005 and LOD(Aspex) = 3.38, empirical p = 0.006).
conclusionsThese regions may harbor imprinted sites associated with the development of autism and offer fruitful domains for molecular investigation into the role of epigenetic mechanisms in autism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.