ArticlePloS one2010
Rapid changes in the light/dark cycle disrupt memory of conditioned fear in mice.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- Metaplastic sleep regulation inbioRxiv : the preprint server for biology · 2026Article
- Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine.Neuroscience and biobehavioral reviews · 2024Review
- Effects of chronic light cycle disruption during adolescence on circadian clock, neuronal activity rhythms, and behavior in mice.Frontiers in neuroscience · 2024Article
- Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation.Journal of biological rhythms · 2023Article
- Resilience by design: How nature, nurture, environment, and microbiome mitigate stress and allostatic load.World journal of psychiatry · 2023Review
- Circadian rhythms in the blood-brain barrier: impact on neurological disorders and stress responses.Molecular brain · 2023Review
- Shift work-like patterns effect on female and male mouse behavior.Neurobiology of sleep and circadian rhythms · 2022Article
- Chronic Exposure to Dim Light at Night or Irregular Lighting Conditions Impact Circadian Behavior, Motor Coordination, and Neuronal Morphology.Frontiers in neuroscience · 2022Article
- Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression.Frontiers in behavioral neuroscience · 2022Article
- Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats.Frontiers in molecular neuroscience · 2022Article
- Article
- Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Effect of photoperiod and light intensity on learning ability and memory formation of the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior.Frontiers in behavioral neuroscience · 2020Article
- Assessment of Sleep, K-Complexes, and Sleep Spindles in a T21 Light-Dark Cycle.Frontiers in neuroscience · 2020Article
- Circadian misalignment has differential effects on affective behavior following exposure to controllable or uncontrollable stress.Behavioural brain research · 2019Article
- Modelling physical resilience in ageing mice.Mechanisms of ageing and development · 2019Review
- Chronic Jet Lag Simulation Decreases Hippocampal Neurogenesis and Enhances Depressive Behaviors and Cognitive Deficits in Adult Male Rats.Frontiers in behavioral neuroscience · 2019Article
- Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal.Frontiers in neurology · 2018Review
- Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions.Neural plasticity · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundCircadian rhythms govern many aspects of physiology and behavior including cognitive processes. Components of neural circuits involved in learning and memory, e.g., the amygdala and the hippocampus, exhibit circadian rhythms in gene expression and signaling pathways. The functional significance of these rhythms is still not understood. In the present study, we sought to determine the impact of transiently disrupting the circadian system by shifting the light/dark (LD) cycle. Such "jet lag" treatments alter daily rhythms of gene expression that underlie circadian oscillations as well as disrupt the synchrony between the multiple oscillators found within the body. METHODOLOGY/PRINCIPAL
findingsWe subjected adult male C57Bl/6 mice to a contextual fear conditioning protocol either before or after acute phase shifts of the LD cycle. As part of this study, we examined the impact of phase advances and phase delays, and the effects of different magnitudes of phase shifts. Under all conditions tested, we found that recall of fear conditioned behavior was specifically affected by the jet lag. We found that phase shifts potentiated the stress-evoked corticosterone response without altering baseline levels of this hormone. The jet lag treatment did not result in overall sleep deprivation, but altered the temporal distribution of sleep. Finally, we found that prior experience of jet lag helps to compensate for the reduced recall due to acute phase shifts. CONCLUSIONS/SIGNIFICANCE: Acute changes to the LD cycle affect the recall of fear-conditioned behavior. This suggests that a synchronized circadian system may be broadly important for normal cognition and that the consolidation of memories may be particularly sensitive to disruptions of circadian timing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.