ArticleMolecular systems biology2010
Emergent cooperation in microbial metabolism.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers.
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Who cites it
169 citing papers in PubMed.
- Reciprocal cross-feeding between bacteria can limit the emergence of metabolic dependencies.Applied and environmental microbiology · 2026Article
- Long-term homeostasis in microbial consortia via auxotrophic cross-feeding.Nature communications · 2025Article
- Competition and cooperation: The plasticity of bacterial interactions across environments.PLoS computational biology · 2025Article
- Targeted recognition, fluorescent tracking and augmented killing of multi-bacterial infectionsChemical science · 2025Article
- Dynamic fluid layer around immotile yeast colonies mediates the spread of bacteria.Biophysical journal · 2025Article
- Metabolic Objectives and Trade-Offs: Inference and Applications.Metabolites · 2025Review
- Carbon source diversity shapes bacterial interspecies interactions.The ISME journal · 2025Article
- Microbial cross-feeding stabilized by segregation of a dependent mutant from its independent ancestor.The ISME journal · 2025Article
- A framework for understanding collective microbiome metabolism.Nature microbiology · 2024Review
- Exploring interspecific interaction variability in microbiota: A review.Engineering microbiology · 2024Review
- Niche-Aware Metagenomic Screening for Enzyme Methioninase Illuminates Its Contribution to Metabolic Syntrophy.Microbial ecology · 2024Article
- Cross-biome microbial networks reveal functional redundancy and suggest genome reduction through functional complementarity.Communications biology · 2024Article
- Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community.Nature communications · 2024Article
- GEM-based computational modeling for exploring metabolic interactions in a microbial community.PLoS computational biology · 2024Article
- Flux sampling in genome-scale metabolic modeling of microbial communities.BMC bioinformatics · 2024Article
- Cross-feeding promotes heterogeneity within yeast cell populations.Nature communications · 2024Article
- Bacterial adenine cross-feeding stems from a purine salvage bottleneck.The ISME journal · 2024Article
- Evolution and synthetic biology.Current opinion in microbiology · 2023Review
- Mutualism reduces the severity of gene disruptions in predictable ways across microbial communities.The ISME journal · 2023Article
- Metabolic exchanges are ubiquitous in natural microbial communities.Nature microbiology · 2023Review
109 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixed microbial communities exhibit emergent biochemical properties not found in clonal monocultures. We report a new type of synthetic genetic interaction, synthetic mutualism in trans (SMIT), in which certain pairs of auxotrophic Escherichia coli mutants complement one another's growth by cross-feeding essential metabolites. We find significant metabolic synergy in 17% of 1035 such pairs tested, with SMIT partners identified throughout the metabolic network. Cooperative phenotypes show more growth on average by aiding the proliferation of their conjugate partner, thereby expanding the source of their own essential metabolites. We construct a quantitative, predictive, framework for describing SMIT interactions as governed by stoichiometric models of the metabolic networks of the interacting strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.