ArticleAnesthesiology2010
Caspase-1 modulates incisional sensitization and inflammation.
Article in Anesthesiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting.CNS neuroscience & therapeutics · 2026Pooled it
- Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Role and uptake of metal-based nanoconstructs as targeted therapeutic carriers for rheumatoid arthritis.3 Biotech · 2024Review
- Inflammatory-associated apoptotic markers: are they the culprit to rheumatoid arthritis pain?Molecular biology reports · 2022Review
- Unveiling Targets for Treating Postoperative Pain: The Role of the TNF-α/p38 MAPK/NF-κB/Nav1.8 and Nav1.9 Pathways in the Mouse Model of Incisional Pain.International journal of molecular sciences · 2022Article
- The Involvement of Caspases in Neuroinflammation and Neuronal Apoptosis in Chronic Pain and Potential Therapeutic Targets.Frontiers in pharmacology · 2022Review
- An Improved Model of Moderate Sleep Apnoea for Investigating Its Effect as a Comorbidity on Neurodegenerative Disease.Frontiers in aging neuroscience · 2022Article
- Article
- A Novel Sex-Dependent Target for the Treatment of Postoperative Pain: The NLRP3 Inflammasome.Frontiers in neurology · 2019Review
- Alcohol accumulation promotes esophagitis via pyroptosis activation.International journal of biological sciences · 2018Article
- Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats.Scientific reports · 2017Article
- Postoperative pain-from mechanisms to treatment.Pain reports · 2017Article
- Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain.Mediators of inflammation · 2017Review
- Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents.Journal of neurophysiology · 2015Article
- Article
- Roles of Gr-1+ leukocytes in postincisional nociceptive sensitization and inflammation.Anesthesiology · 2012Article
- miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.Anesthesiology · 2012Article
- Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat.Journal of neurophysiology · 2012Article
- The complement component C5a receptor mediates pain and inflammation in a postsurgical pain model.Pain · 2012Article
- Increased local concentration of complement C5a contributes to incisional pain in mice.Journal of neuroinflammation · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSurgical injury induces production and release of inflammatory mediators in the vicinity of the wound. They in turn trigger nociceptive signaling to produce hyperalgesia and pain. Interleukin-1β plays a crucial role in this process. The mechanism regulating production of this cytokine after incision is, however, unknown. Caspase-1 is a key enzyme that cleaves prointerleukin-1β to its active form. We hypothesized that caspase-1 is a crucial regulator of incisional interleukin-1β levels, nociceptive sensitization, and inflammation.
methodsThese studies employed a mouse hind paw incisional model. Caspase-1 was blocked using the selective inhibitors Ac-YVAD-CMK and VRTXSD727. Nociceptive sensitization, edema, and hind paw warmth were followed in intact animals whereas caspase-1 activity, cytokine, and prostaglandin E2 levels were assessed in homogenized skin. Confocal microscopy was used to detect the expression of caspase-1 near the wounds.
resultsAnalysis of enzyme activity demonstrated that caspase-1 activity was significantly increased in periincisional skin. Pretreatment with Ac-YVAD-CMK significantly reduced mechanical allodynia and thermal hyperalgesia. Repeated administration of this inhibitor produced robust analgesia, especially to mechanical stimulation. Administration of VRTXSD727 provided qualitatively similar results. Caspase-1 inhibition also reduced edema and the normally observed increase in paw warmth around the wound site. Correspondingly, caspase-1 inhibition significantly reduced interleukin-1β as well as macrophage-inflammatory protein 1α, granulocyte colony-stimulating factor, and prostaglandin E2 levels near the wound. The expression of caspase-1 was primarily observed in keratinocytes in the epidermal layer and in neutrophils deeper in the wounds.
conclusionsThe current study demonstrates that the inhibition of caspase-1 reduces postsurgical sensitization and inflammation, likely through a caspase-1/interleukin-1β-dependent mechanism.
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