ArticleBiofabrication2010
Hippocampal neurons respond uniquely to topographies of various sizes and shapes.
Article in Biofabrication, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Iron-Chelated Silk Microfiber/Hydrogel Composites as Injectable, Magnetically Aligned Cell Guidance Scaffolds.Advanced healthcare materials · 2026Article
- A Neuroelectronic Interface with Microstructured Substrates for Spiral Ganglion Neurons Cultured In Vitro: Proof of Concept.Biosensors · 2025Article
- Engineered cell culture microenvironments for mechanobiology studies of brain neural cells.Frontiers in bioengineering and biotechnology · 2022Review
- Multiscale Mechanobiology in Brain Physiology and Diseases.Frontiers in cell and developmental biology · 2022Review
- Multi-curvature micropatterns unveil distinct calcium and mitochondrial dynamics in neuronal networks.Lab on a chip · 2021Article
- Effect of Electrical and Electromechanical Stimulation on PC12 Cell Proliferation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2021Article
- Cellular and Subcellular Contact Guidance on Microfabricated Substrates.Frontiers in bioengineering and biotechnology · 2020Review
- Recent advances in nanotherapeutic strategies for spinal cord injury repair.Advanced drug delivery reviews · 2019Review
- Digital Manufacturing for Microfluidics.Annual review of biomedical engineering · 2019Review
- Modulating physical, chemical, and biological properties in 3D printing for tissue engineering applications.Applied physics reviews · 2018Article
- Rapid continuous 3D printing of customizable peripheral nerve guidance conduits.Materials today (Kidlington, England) · 2018Article
- Advantageous environment of micro-patterned, high-density complementary metal-oxide-semiconductor electrode array for spiral ganglion neurons cultured in vitro.Scientific reports · 2018Article
- Microelectrode array-induced neuronal alignment directs neurite outgrowth: analysis using a fast Fourier transform (FFT).European biophysics journal : EBJ · 2017Article
- Characterization of dorsal root ganglion neurons cultured on silicon micro-pillar substrates.Scientific reports · 2016Article
- Intracellular calcium and cyclic nucleotide levels modulate neurite guidance by microtopographical substrate features.Journal of biomedical materials research. Part A · 2016Article
- Titania nanotube arrays as interfaces for neural prostheses.Materials science & engineering. C, Materials for biological applications · 2015Article
- Film-based Implants for Supporting Neuron-Electrode Integrated Interfaces for The Brain.Advanced functional materials · 2014Article
- Neuronal electrophysiological function and control of neurite outgrowth on electrospun polymer nanofibers are cell type dependent.Tissue engineering. Part A · 2014Article
- Neural responses to electrical stimulation on patterned silk films.Journal of biomedical materials research. Part A · 2013Article
- A patterned recombinant human IgM guides neurite outgrowth of CNS neurons.Scientific reports · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A number of studies have investigated the behavior of neurons on microfabricated topography for the purpose of developing interfaces for use in neural engineering applications. However, there have been few studies simultaneously exploring the effects of topographies having various feature sizes and shapes on axon growth and polarization in the first 24 h. Accordingly, here we investigated the effects of arrays of lines (ridge grooves) and holes of microscale (approximately 2 microm) and nanoscale (approximately 300 nm) dimensions, patterned in quartz (SiO2), on the (1) adhesion, (2) axon establishment (polarization), (3) axon length, (4) axon alignment and (5) cell morphology of rat embryonic hippocampal neurons, to study the response of the neurons to feature dimension and geometry. Neurons were analyzed using optical and scanning electron microscopy. The topographies were found to have a negligible effect on cell attachment but to cause a marked increase in axon polarization, occurring more frequently on sub-microscale features than on microscale features. Neurons were observed to form longer axons on lines than on holes and smooth surfaces; axons were either aligned parallel or perpendicular to the line features. An analysis of cell morphology indicated that the surface features impacted the morphologies of the soma, axon and growth cone. The results suggest that incorporating microscale and sub-microscale topographies on biomaterial surfaces may enhance the biomaterials' ability to modulate nerve development and regeneration.
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Registered trials
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