ArticleProceedings of the National Academy of Sciences of the United States of America2010
Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor-ligand bridge protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Engineering multiple levels of specificity in an RNA viral vector.Nature communications · 2026Article
- Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses.Neuroscience bulletin · 2019Review
- Multiplex Neural Circuit Tracing With G-Deleted Rabies Viral Vectors.Frontiers in neural circuits · 2019Article
- Regulation of Synapse Development byThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Optogenetic Modulation of Intracellular Signalling and Transcription: Focus on Neuronal Plasticity.Journal of experimental neuroscience · 2017Review
- Strategies for targeting primate neural circuits with viral vectors.Journal of neurophysiology · 2016Review
- Neuroanatomy goes viral!Frontiers in neuroanatomy · 2015Review
- An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology.Brain structure & function · 2015Article
- Classic selective sweeps revealed by massive sequencing in cattle.PLoS genetics · 2014Article
- Revisiting enigmatic cortical calretinin-expressing interneurons.Frontiers in neuroanatomy · 2014Review
- Design and generation of recombinant rabies virus vectors.Nature protocols · 2013Article
- Axonal and subcellular labelling using modified rabies viral vectors.Nature communications · 2013Article
- Article
- Revealing the secrets of neuronal circuits with recombinant rabies virus technology.Frontiers in neural circuits · 2013Review
- Optogenetic investigation of neural circuits underlying brain disease in animal models.Nature reviews. Neuroscience · 2012Review
- Viral vector-based reversible neuronal inactivation and behavioral manipulation in the macaque monkey.Frontiers in systems neuroscience · 2012Article
- Monosynaptic inputs to ErbB4-expressing inhibitory neurons in mouse primary somatosensory cortex.The Journal of comparative neurology · 2011Article
- Virally mediated gene manipulation in the adult CNS.Frontiers in molecular neuroscience · 2011Article
- New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits.Neuron · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Both treatment of disease and basic studies of complex tissues can benefit from directing viral vector infection to specific cell types. We have used a unique cell targeting method to direct viral vector transduction to cerebral cortical neurons expressing the neuregulin (NRG) receptor ErbB4; both NRG and ErbB4 have been implicated in schizophrenia, and ErbB4 expression in cerebral cortex is known to be restricted to inhibitory neurons. We find that a bridge protein composed of the avian viral receptor TVB fused to NRG, along with EnvB-pseudotyped virus, is able to direct infection selectively to ErbB4-expressing inhibitory cortical neurons in vivo. Interestingly, although ErbB4 is expressed in a broad range of cortical inhibitory cell types, NRG-dependent infection is restricted to a more selective subset of inhibitory cell types. These results demonstrate a tool that can be used for further studies of NRG and ErbB receptors in brain circuits and demonstrate the feasibility for further development of related bridge proteins to target gene expression to other specific cell types in complex tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.