ArticleProceedings of the National Academy of Sciences of the United States of America2010
Scaling expectations for the time to establishment of complex adaptations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein.PLoS genetics · 2026Article
- SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution.bioRxiv : the preprint server for biology · 2025Article
- Mutation Rate and Effective Population Size of the Model Cooperative Bacterium Myxococcus xanthus.Genome biology and evolution · 2024Article
- Mutation pressure, drift, and the pace of molecular coevolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Inferring the distribution of fitness effects in patient-sampled and experimental virus populations: two case studies.Heredity · 2022Article
- Imposed mutational meltdown as an antiviral strategy.Evolution; international journal of organic evolution · 2020Review
- Population genomics of rapid evolution in natural populations: polygenic selection in response to power station thermal effluents.BMC evolutionary biology · 2019Article
- Regulatory mechanism predates the evolution of self-organizing capacity in simulated ant-like robots.Communications biology · 2019Article
- Decimation by sea star wasting disease and rapid genetic change in a keystone species,Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Evolution of complex adaptations in molecular systems.Nature ecology & evolution · 2017Article
- Adaptive evolution of complex innovations through stepwise metabolic niche expansion.Nature communications · 2016Article
- Article
- Evolutionary history of a complex adaptation: tetrodotoxin resistance in salamanders.Evolution; international journal of organic evolution · 2015Article
- Epigenetic resolution of the 'curse of complexity' in adaptive evolution of complex traits.The Journal of physiology · 2014Article
- Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA.PloS one · 2014Article
- Population genomics of rapid adaptation by soft selective sweeps.Trends in ecology & evolution · 2013Review
- The genetic basis of speciation in the Giliopsis lineage of Ipomopsis (Polemoniaceae).Heredity · 2013Article
- Article
- FFPopSim: an efficient forward simulation package for the evolution of large populations.Bioinformatics (Oxford, England) · 2012Article
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Abstract
Although the vast majority of research in evolutionary biology is focused on adaption, a general theory for the population-genetic mechanisms by which complex adaptations are acquired remains to be developed. The issue explored here is the procurement of novel traits that specifically require multiple mutations to achieve a fitness advantage. By highlighting the roles played by the forces of mutation, recombination, and random genetic drift, and drawing from observations on the joint constraints on these factors, the ways in which rates of acquisition of specific types of adaptations scale with population size are explored. These general results provide insight into a number of ongoing controversies regarding the molecular basis of adaptation, including the adaptive utility of recombination and the role of drift in the passage through adaptive valleys.
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