ArticleInfection and immunity2010
Branched-chain fatty acids promote Listeria monocytogenes intracellular infection and virulence.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Understanding the role of pyruvate dehydrogenase inInfection and immunity · 2026Article
- Feeding the invaders: how metabolic imbalance shapes infection and biofilm development.FEMS microbiology reviews · 2026Review
- Bacterial acquisition of host fatty acids has far-reaching implications on virulence.Microbiology and molecular biology reviews : MMBR · 2024Review
- An insight into the role of branched-chain α-keto acid dehydrogenase (BKD) complex in branched-chain fatty acid biosynthesis and virulence ofJournal of bacteriology · 2024Article
- Anti-infective activities of long-chain fatty acids against foodborne pathogens.FEMS microbiology reviews · 2023Review
- Identification of genetic elements required forFrontiers in microbiology · 2022Article
- Unravelling the Molecular Mechanisms Underlying the Protective Effect of Lactate on the High-Pressure Resistance ofBiomolecules · 2021Article
- The Opposing Role of Propionate in ModulatingFrontiers in microbiology · 2021Article
- Article
- Two PrevalentFrontiers in veterinary science · 2020Article
- Metabolism of the Gram-Positive Bacterial PathogenMicrobiology spectrum · 2019Review
- Taxonomic and functional heterogeneity of the gill microbiome in a symbiotic coastal mangrove lucinid species.The ISME journal · 2019Article
- Review
- Article
- Listeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity.Cellular microbiology · 2017Review
- Metabolic Genetic Screens Reveal Multidimensional Regulation of Virulence Gene Expression in Listeria monocytogenes and an Aminopeptidase That Is Critical for PrfA Protein Activation.Infection and immunity · 2017Article
- Utilization of multiple substrates by butyrate kinase from Listeria monocytogenes.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Article
- Biological Functions ofFrontiers in microbiology · 2017Article
- Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria monocytogenes.Infection and immunity · 2016Article
- The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence.Molecular microbiology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Anteiso-branched-chain fatty acids (BCFA) represent the dominant group of membrane fatty acids and have been established as crucial determinants in resistance against environmental stresses in Listeria monocytogenes, a facultative intracellular pathogen. Here, we investigate the role of anteiso-BCFA in L. monocytogenes virulence by using mutants deficient in branched-chain alpha-keto acid dehydrogenase (BKD), an enzyme complex involved in the synthesis of BCFA. In tissue culture models of infection, anteiso-BCFA contributed to intracellular growth and survival in macrophages and significantly enhanced plaque formation upon prolonged infection in L2 fibroblasts. The intracellular defects observed could be attributed partially to insufficient listeriolysin O (LLO) production, indicating a requirement for anteiso-BCFA in regulating virulence factor production. In a murine model of infection, the BKD-deficient mutant was highly attenuated, further emphasizing the importance of BKD-mediated metabolism in L. monocytogenes virulence. This study demonstrates an underappreciated role for BCFA in bacterial pathogenesis, which may provide insight into the development and application of antimicrobial agents.
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