ArticleDiabetes2010
Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02802566 (BMI-Based Prenatal Vitamins to Ameliorate Oxidative Stress in Obese Pregnancy), which is not on this map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BMI-Based Prenatal Vitamins to Ameliorate Oxidative Stress in Obese Pregnancy
Who cites it
60 citing papers in PubMed.
- Supplementation with antioxidant micronutrients in pregnant women with obesity: a randomized controlled trial.International journal of obesity (2005) · 2024Trial
- Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women.Nutrients · 2019Trial
- Maternal BMI and Diet Quality Modulate Pregnancy Oxidative and Inflammatory Homeostasis.Nutrients · 2025Observational
- Altered DNA methylation and Dnmt expression in obese uterus may cause implantation failure.Journal of molecular histology · 2024Article
- Article
- Nutriepigenomics in Environmental-Associated Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Review
- Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring.The Proceedings of the Nutrition Society · 2022Review
- The Association of Dietary Total Antioxidant Capacity with Inflammatory Biomarkers and Anthropometric Indices in Patients Who Candidate for Coronary Artery Bypass Graft Surgery: a Cross-sectional Study.Clinical nutrition research · 2021Article
- Maternal diet in pregnancy is associated with differences in child body mass index trajectories from birth to adolescence.The American journal of clinical nutrition · 2021Article
- Article
- Understanding the Link Between Maternal Overnutrition, Cardio-Metabolic Dysfunction and Cognitive Aging.Frontiers in neuroscience · 2021Review
- Strengths and validity of three methods for assessing rat body fat across the life course.International journal of obesity (2005) · 2020Article
- Developmental programming of insulin resistance: are androgens the culprits?The Journal of endocrinology · 2020Review
- Serum Microelements in Early Pregnancy and their Risk of Large-for-Gestational Age Birth Weight.Nutrients · 2020Article
- Role of Dietary Amino Acids and Nutrient Sensing System in Pregnancy Associated Disorders.Frontiers in pharmacology · 2020Review
- Prenatal Steroids and Metabolic Dysfunction: Lessons from Sheep.Annual review of animal biosciences · 2019Review
- Higher dietary magnesium intake is associated with lower body mass index, waist circumference and serum glucose in Mexican adults.Nutrition journal · 2018Article
- Epigenetic control of variation and stochasticity in metabolic disease.Molecular metabolism · 2018Review
- Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse.Biology of reproduction · 2018Article
- Different Statistical Approaches to Characterization of Adipocyte Size in Offspring of Obese Rats: Effects of Maternal or Offspring Exercise Intervention.Frontiers in physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectiveObesity in pregnancy significantly increases the risk of the offspring developing obesity after birth. The aims of this study were to test the hypothesis that maternal obesity increases oxidative stress during fetal development, and to determine whether administration of an antioxidant supplement to pregnant Western diet-fed rats would prevent the development of adiposity in the offspring. RESEARCH DESIGN AND
methodsFemale Sprague Dawley rats were started on the designated diet at 4 weeks of age. Four groups of animals were studied: control chow (control); control + antioxidants (control+Aox); Western diet (Western); and Western diet + antioxidants (Western+Aox). The rats were mated at 12 to 14 weeks of age, and all pups were weaned onto control diet.
resultsOffspring from dams fed the Western diet had significantly increased adiposity as early as 2 weeks of age as well as impaired glucose tolerance compared with offspring of dams fed a control diet. Inflammation and oxidative stress were increased in preimplantation embryos, fetuses, and newborns of Western diet-fed rats. Gene expression of proadipogenic and lipogenic genes was altered in fat tissue of rats at 2 weeks and 2 months of age. The addition of an antioxidant supplement decreased adiposity and normalized glucose tolerance. CONCLUSIONS; Inflammation and oxidative stress appear to play a key role in the development of increased adiposity in the offspring of Western diet-fed pregnant dams. Restoration of the antioxidant balance during pregnancy in the Western diet-fed dam is associated with decreased adiposity in offspring.
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Registered trials
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