ArticleDevelopment (Cambridge, England)2010
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- α-Parvin regulation of cell rearrangement is critical for ureteric bud branching morphogenesis.Science advances · 2026Article
- Integrin-linked kinase promotes hepatic fat accumulation via F-actin stabilization-dependent CD36 plasma membrane localization.iScience · 2026Article
- Kindlins regulate integrin- and growth factor-dependent ureteric bud formation.Development (Cambridge, England) · 2026Article
- The biological function of integrin-linked kinase on bone formation.Bone reports · 2025Review
- Integrins in the kidney - beyond the matrix.Nature reviews. Nephrology · 2025Review
- Inhibition of Integrin-Associated Kinases FAK and ILK on the In Vitro Model of Skin Wound Healing.Applied biochemistry and biotechnology · 2024Article
- Identification of a comprehensive alternative splicing function during epithelial-mesenchymal transition.iScience · 2023Article
- Annexin A2-Mediated Internalization ofMicroorganisms · 2021Article
- Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.Oxidative medicine and cellular longevity · 2020Article
- Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.Journal of the American Society of Nephrology : JASN · 2019Article
- Rsu1-dependent control of PTEN expression is regulated via ATF2 and cJun.Journal of cell communication and signaling · 2019Article
- FGF Gradient Controls Boundary Position Between Proliferating and Differentiating Cells and Regulates Lacrimal Gland Growth Dynamics.Frontiers in genetics · 2019Article
- Regulation of Renal Differentiation by Trophic Factors.Frontiers in physiology · 2018Review
- Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2017Article
- Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8.Journal of the American Society of Nephrology : JASN · 2016Article
- Signaling during Kidney Development.Cells · 2015Review
- Selective regulation of p38β protein and signaling by integrin-linked kinase mediates bladder cancer cell migration.Oncogene · 2014Article
- β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells.PloS one · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
The integrin-linked kinase (ILK), pinch and parvin ternary complex connects the cytoplasmic tails of beta1 integrins to the actin cytoskeleton. We recently showed that constitutive expression of ILK and alpha parvin in both the ureteric bud and the metanephric mesenchyme of the kidney is required for kidney development. In this study, we define the selective role of ILK in the ureteric bud of the mouse kidney in renal development by deleting it in the ureteric cell lineage before the onset of branching morphogenesis (E10.5). Although deleting ILK resulted in only a moderate decrease in branching, the mice died at 8 weeks of age from obstruction due to the unprecedented finding of intraluminal collecting duct cellular proliferation. ILK deletion in the ureteric bud resulted in the inability of collecting duct cells to undergo contact inhibition and to activate p38 mitogen-activated protein kinase (MAPK) in vivo and in vitro. p38 MAPK activation was not dependent on the kinase activity of ILK. Thus, we conclude that ILK plays a crucial role in activating p38 MAPK, which regulates cell cycle arrest of epithelial cells in renal tubulogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.