Trial reportEnvironmental health perspectives2010
Vascular effects of ultrafine particles in persons with type 2 diabetes.
Trial report in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Systematic review of the effects of black carbon on cardiovascular disease among individuals with pre-existing disease.International journal of public health · 2013Pooled it
- Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans.Scientific reports · 2019Trial
- Trial
- Cardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1.Inhalation toxicology · 2015Trial
- Inhalation of ultrafine carbon particles alters heart rate and heart rate variability in people with type 2 diabetes.Particle and fibre toxicology · 2014Trial
- Longitudinal changes in cardiovascular disease-related proteins in welders.International archives of occupational and environmental health · 2024Article
- Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease.International journal of molecular sciences · 2022Review
- [Effects of ultrafine particulates on cardiac function in rat isolated heart].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Different metrics (number, surface area, and volume concentration) of urban particles with varying sizes in relation to fractional exhaled nitric oxide (FeNO).Journal of thoracic disease · 2019Article
- Ambient and controlled exposures to particulate air pollution and acute changes in heart rate variability and repolarization.Scientific reports · 2019Article
- In Vitro and In Vivo Experimental Studies of PMInternational journal of environmental research and public health · 2018Review
- Ambient air pollution and thrombosis.Particle and fibre toxicology · 2018Review
- Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects.Journal of occupational medicine and toxicology (London, England) · 2018Article
- Multicenter Ozone Study in oldEr Subjects (MOSES): Part 1. Effects of Exposure to Low Concentrations of Ozone on Respiratory and Cardiovascular Outcomes.Research report (Health Effects Institute) · 2017Article
- Triggering of ST-elevation myocardial infarction by ambient wood smoke and other particulate and gaseous pollutants.Journal of exposure science & environmental epidemiology · 2017Article
- Ambient Particulate Matter (PMJournal of epidemiology · 2016Article
- Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study.Journal of toxicology and environmental health. Part A · 2016Article
- Medication type modifies inflammatory response to traffic exposure in a population with type 2 diabetes.Environmental pollution (Barking, Essex : 1987) · 2015Article
- Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China.Particle and fibre toxicology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDiabetes confers an increased risk for cardiovascular effects of airborne particles.
objectiveWe hypothesized that inhalation of elemental carbon ultrafine particles (UFP) would activate blood platelets and vascular endothelium in people with type 2 diabetes.
methodsIn a randomized, double-blind, crossover trial, 19 subjects with type 2 diabetes inhaled filtered air or 50 µg/m³ elemental carbon UFP (count median diameter, 32 nm) by mouthpiece for 2 hr at rest. We repeatedly measured markers of vascular activation, coagulation, and systemic inflammation before and after exposure.
resultsCompared with air, particle exposure increased platelet expression of CD40 ligand (CD40L) and the number of platelet-leukocyte conjugates 3.5 hr after exposure. Soluble CD40L decreased with UFP exposure. Plasma von Willebrand factor increased immediately after exposure. There were no effects of particles on plasma tissue factor, coagulation factors VII or IX, or D-dimer.
conclusionsInhalation of elemental carbon UFP for 2-hr transiently activated platelets, and possibly the vascular endothelium, in people with type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.