Evidence map›Paper›PMID 20822942›Full record

Trial reportEuropean journal of pain (London, England)2011

Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain.

Felipe Fregni, Kimberly Potvin, Deborah Dasilva, Xiaoen Wang, Robert E Lenkinski, Steven D Freedman, Alvaro Pascual-Leone

Registry-linked trialAbstract readClinical Trial, Phase IIControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of pain (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01857492 (tDCS for the Management of Chronic Visceral Pain in Patients With Chronic Pancreatitis), which is not on this map. Cited by 34 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 8 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01857492 nawithdrawnnot on this mapstarted 2013, after this paper: background citation

tDCS for the Management of Chronic Visceral Pain in Patients With Chronic Pancreatitis

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2013 to 2014Enrolled0ConditionsChronic Pancreatitis, PainArmstDCS, Meditation
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 8 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018
    Pooled it
  5. Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018
    Pooled it
  6. Systematic review of early surgery for chronic pancreatitis: impact on pain, pancreatic function, and re-intervention.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Article
  12. Review
  13. Review
  14. Cortical stimulation for chronic pain: from anecdote to evidence.European journal of physical and rehabilitation medicine · 2022
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Felipe FregniBerenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. ffregni@bidmc.harvard.edu
Kimberly Potvin
Deborah Dasilva
Xiaoen Wang
Robert E Lenkinski
Steven D Freedman
Alvaro Pascual-Leone
Beth Israel Deaconess Medical Center · USBerenson Allen Center for Noninvasive Brain Stimulation · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 1985 to 2008
$37.4M
Study and Modulation of Brian PlasticityK24RR018875 · NCRR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2004 to 2008
$602k
Investigation and treatment of central nervous system dysfunction in chronic pelvR21DK081773 · NIDDK · SPAULDING REHABILITATION HOSPITAL · PI FREGNI, FELIPE · 2009 to 2010
$475k
TMS treatment for pain in chronic pancreatitisR03DK071851 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FREEDMAN, STEVEN DAVID · 2005 to 2006
$336k
NCRR NIH HHS K24 RR018875NCRR NIH HHS M01 RR001066NCRR NIH HHS M01-RR-01066NCRR NIH HHS UL1 RR025758NIDDK NIH HHS R03 DK071851NIDDK NIH HHS R21 DK081773NIDDK NIH HHS R21DK081773
6 · The paper itself

Abstract

BACKGROUND AND

aimsChronic visceral pain is frequent, extremely debilitating, and generally resistant to pharmacological treatment. It has been shown that chronic visceral inflammation, through altered afferent visceral sensory input, leads to plastic changes in the central nervous system that ultimately sustain pain. Therefore approaches aiming at modulation of brain activity are attractive candidates to control visceral pain.

methodsHere we report findings of a phase II, sham-controlled clinical trial assessing the clinical effects and brain metabolic correlates of a 10-day course of daily sessions of slow-frequency, repetitive transcranial magnetic stimulation (rTMS) targeting the right secondary somatosensory cortex (SII) in patients with chronic pancreatitis and severe visceral pain.

resultsOur results show a significant reduction in pain after real rTMS that lasted for at least 3 weeks following treatment. These clinical changes were correlated with increases in glutamate and N-acetyl aspartate (NAA) levels--neurometabolites associated with cortical activity and brain damage--as measured by in vivo single-voxel proton magnetic resonance spectroscopy (1H-MRS). Adverse effects in the real rTMS group were mild and short-lasting.

conclusionsOur results support preliminary findings showing that modulation of right SII with rTMS is associated with a significant analgesic effect and that this effect is correlated with an increase in excitatory neurotransmitter levels such as glutamate and NAA.

Indexed as

Magnetic Resonance SpectroscopyPain ManagementTranscranial Magnetic StimulationAdultAnalgesiaAspartic AcidBrainChronic DiseaseFemaleGlutamic AcidHumansMaleMiddle AgedPainPancreatitis, ChronicRadionuclide ImagingAspartic AcidGlutamic AcidN-acetylaspartate

Identifiers

PMID20822942
PMCPMC3000866
OpenAlexW2153331462

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.