ArticleJournal of autoimmunity2010
Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses.
Article in Journal of autoimmunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Aberrant expression of MERTK activates BCR via CD79a in CLL cells: alternative therapeutic strategy for relapsed/refractory CLL.Leukemia · 2026Article
- Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Relationship between the tumor microenvironment and the efficacy of the combination of radiotherapy and immunotherapy.International review of cell and molecular biology · 2023Article
- Tuberculosis and Autoimmunity.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022Review
- Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages.Cell death & disease · 2021Article
- B cell responses to apoptotic cells in MFG-E8-/- mice.PloS one · 2018Article
- Increased Mer and Axl receptor tyrosine kinase expression on glomeruli in lupus nephritis.Clinical rheumatology · 2017Article
- Stat1 Regulates Lupus-like Chronic Graft-versus-Host Disease Severity via Interactions with Stat3.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The expression and clinical significance of different forms of Mer receptor tyrosine kinase in systemic lupus erythematosus.Journal of immunology research · 2014Article
- Biology of the TAM receptors.Cold Spring Harbor perspectives in biology · 2013Review
- MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.The Journal of clinical investigation · 2013Article
- Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice.Autoimmunity · 2013Article
- Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Intrinsic unresponsiveness of Mertk-/- B cells to chronic graft-versus-host disease is associated with unmodulated CD1d expression.Journal of autoimmunity · 2012Article
- Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens.Arthritis and rheumatism · 2012Article
- Impaired clearance of apoptotic cells in germinal centers: implications for loss of B cell tolerance and induction of autoimmunity.Immunologic research · 2011Review
- Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.PloS one · 2011Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Control of lymphocyte homeostasis is essential to ensure efficient immune responses and to prevent autoimmunity. Splenic marginal zone B cells are important producers of autoantibodies, and are subject to stringent tolerance mechanisms to prevent autoimmunity. In this paper, we explore the role of the Mer tyrosine kinase (Mertk) in regulating autoreactive B cells. This receptor tyrosine kinase serves to bind apoptotic cells, to mediate their phagocytosis, and to regulate subsequent cytokine production. Mice lacking Mertk suffer from impaired apoptotic cell clearance and develop a lupus-like autoimmune syndrome. Here we show that such Mertk-KO mice have expanded numbers of splenic marginal zone B cells. Mertk-KO mice bearing a DNA-specific immunoglobulin heavy-chain transgene (3H9) produced anti-DNA antibodies that appeared to be secreted largely by marginal zone B cells. Finally, Mertk-KO mice developed greater antibody responses after NP-Ficoll immunization than their B6 counterparts. Taken together, our data show that Mertk has a major effect on the development of the marginal zone B-cell compartment. Mertk is also important in establishing DNA-specific B-cell tolerance in 3H9 anti-DNA transgenic mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.