ArticleCell communication and signaling : CCS2010
Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions.
Article in Cell communication and signaling : CCS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Cell-cell communication: new insights and clinical implications.Signal transduction and targeted therapy · 2024Review
- Combined Application of Patient-Derived Cells and Biomaterials as 3D In Vitro Tumor Models.Cancers · 2022Article
- Angiogenesis Inhibitors and Immunomodulation in Renal Cell Cancers: The Past, Present, and Future.Cancers · 2022Review
- Angiogenesis: A Pivotal Therapeutic Target in the Drug Development of Gynecologic Cancers.Cancers · 2022Review
- Research and application of hydrostatic high pressure in tumor vaccines (Review).Oncology reports · 2021Review
- Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer.Journal of hematology & oncology · 2020Article
- Article
- Analysis of IMP3 expression in primary tumor and stromal cells in patients with colorectal cancer.Oncology letters · 2017Article
- Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development.Stem cells translational medicine · 2017Review
- Metastasis: Other Side of the Coin.Frontiers in oncology · 2015Review
- Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners.Current pathobiology reports · 2014Article
- Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5).Clinical & experimental metastasis · 2014Article
- Microenvironment-a role in tumour progression and prognosis.Journal of clinical and diagnostic research : JCDR · 2013Article
- Role of the nervous system in cancer metastasis.Oncology letters · 2013Article
- Potentiation of tumor cell invasion by co-culture with monocytes accompanying enhanced production of matrix metalloproteinase and fibronectin.Clinical & experimental metastasis · 2013Article
- Postoperative simple biochemical markers for prediction of bone metastases in Egyptian breast cancer patients.Ecancermedicalscience · 2013Article
- Article
- Mechanobiology of tumor invasion: engineering meets oncology.Critical reviews in oncology/hematology · 2012Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in tumor biology led to the realization that, in order to understand the mechanisms involved in proliferation and invasion of tumor cells, an analysis of the complex interactions that tumor cells establish with host cells of tumor microenvironment is required. The bidirectional interactions between tumor cells and components of tumor microenvironment, in particular endothelial cells, cells of monocyte/macrophage lineage and fibroblasts/myofibroblasts, play a critical role in most of the events that characterize tumor progression and metastasis. Interactions between these "reactive" normal cells and the genetically altered tumor cells, by either cell-to-cell contacts or soluble mediators, control the most aspects of tumor formation and progression. This review addresses some of the experimental evidences documenting that tumor cells may influence host cells of their own microenvironment by triggering changes that facilitate their local as well as distant dissemination. Therefore, it focuses on macrophages and fibroblasts that, upon stimulation by tumor cells, change their state towards a tumor-promoting-like phenotype.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.