ReviewExpert review of vaccines2010
Anti-cocaine vaccine development.
Review in Expert review of vaccines, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Vaccines as a preventive tool for substance use disorder: A systematic review including a meta-analysis on nicotine vaccines' immunogenicity.Human vaccines & immunotherapeutics · 2022Pooled it
- Substance abuse and inflammation: consequences beyond the brain.Trends in immunology · 2026Review
- A synthetic cyclic peptide for promoting antigen presentation and immune activation.NPJ vaccines · 2025Article
- Immunotherapeutic strategies for treating opioid use disorder and overdose.Expert opinion on investigational drugs · 2023Review
- Pre-clinical safety and toxicology profile of a candidate vaccine to treat oxycodone use disorder.Vaccine · 2022Article
- Calix[Journal of advanced research · 2022Article
- Cocaine Use Disorder (CUD): Current Clinical Perspectives.Substance abuse and rehabilitation · 2022Review
- Bivalent Conjugate Vaccine Induces Dual Immunogenic Response That Attenuates Heroin and Fentanyl Effects in Mice.Bioconjugate chemistry · 2021Article
- Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid.Nature biomedical engineering · 2021Article
- Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl Analogues.Molecular pharmaceutics · 2020Article
- Environmental, genetic and epigenetic contributions to cocaine addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Hapten-specific naïve B cells are biomarkers of vaccine efficacy against drugs of abuse.Journal of immunological methods · 2014Article
- Probing the effects of hapten stability on cocaine vaccine immunogenicity.Molecular pharmaceutics · 2013Article
- Substance use disorders: psychoneuroimmunological mechanisms and new targets for therapy.Pharmacology & therapeutics · 2013Review
- Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites.PloS one · 2013Article
- Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy.Drug and alcohol dependence · 2012Review
- AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior.Human gene therapy · 2012Article
- Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities.Biochemical pharmacology · 2012Article
- Are pharmacokinetic approaches feasible for treatment of cocaine addiction and overdose?Future medicinal chemistry · 2012Article
- Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity.Future medicinal chemistry · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cocaine abuse is an ongoing and serious problem that has led to the growth of a brutal criminal enterprise, particularly in the Americas and Europe. At present, there are no effective pharmacological agents available to treat the addiction by blocking cocaine or reversing its effects. In order to help motivated addicts conquer their addiction, vaccines against cocaine are being developed and one has progressed to clinical trials. This article will discuss the concept of antidrug vaccines in general, the successes and limitations of the various anti-cocaine vaccine approaches, the results of the clinical trials with an anti-cocaine vaccine and some new vaccine-mediated approaches to combat cocaine addiction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.