ArticlePharmaceutical biology2011
Antipyretic and antinociceptive effects of Nauclea latifolia root decoction and possible mechanisms of action.
Article in Pharmaceutical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 81 citations in OpenAlex.
- Neuroprotection by Nauclea latifolia extract in arsenite & high-fat diet-induced brain stress.Environmental analysis, health and toxicology · 2025Article
- Polyphenols and extracts fromFrontiers in pharmacology · 2024Article
- Antipyretic Potential of 80% Methanol Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Succinimido-Ferrocidiphenol Complexed with Cyclodextrins Inhibits Glioblastoma Tumor Growth In Vitro and In Vivo without Noticeable Adverse Toxicity.Molecules (Basel, Switzerland) · 2022Article
- Protective Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Black-box modelling, bi-objective optimization and ASPEN batch simulation of phenolic compound extraction fromHeliyon · 2021Article
- Therapeutic Uses of Red Macroalgae.Molecules (Basel, Switzerland) · 2020Review
- A novel triterpenoid 16-hydroxy betulinic acid isolated fromSaudi journal of biological sciences · 2019Article
- Investigation of nepetolide as a novel lead compound: Antioxidant, antimicrobial, cytotoxic, anticancer, anti-inflammatory, analgesic activities and molecular docking evaluation.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures.BMC complementary and alternative medicine · 2016Article
- Antinociceptive activity of Euadenia trifoliolata (Schum. & Thonn.) Oliv. leaves and roots in mice.Journal of traditional and complementary medicine · 2016Article
- In vitro study on the antioxidant potentials of the leaves and fruits of Nauclea latifolia.TheScientificWorldJournal · 2014Article
- In vitro anti-Herpes simplex virus activity of crude extract of the roots of Nauclea latifolia Smith (Rubiaceae).BMC complementary and alternative medicine · 2013Article
- Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferation.BMC complementary and alternative medicine · 2013Article
- Ethnopharmacological Survey of Plants Used in the Traditional Treatment of Gastrointestinal Pain, Inflammation and Diarrhea in Africa: Future Perspectives for Integration into Modern Medicine.Animals : an open access journal from MDPI · 2013Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextNauclea latifolia Smith (Rubiaceae) is a small tree found in tropical areas in Africa. It is used in traditional medicine to treat malaria, epilepsy, anxiety, pain, fever, etc.
objectiveThe aim of this study was to investigate the effects of Nauclea latifolia roots decoction on the peripheral and central nervous systems and its possible mechanisms of action. MATERIALS AND
methodsThe analgesic investigation was carried out against acetic acid-induced writhing, formalin-induced pain, hot-plate and tail immersion tests. The antipyretic activity was studied in Brewer's yeast-induced pyrexia in mice. Rota-rod test and bicuculline-induced hyperactivity were used for the assessment of locomotor activity.
resultsNauclea latifolia induced hypothermia and had antipyretic effects in mice. The plant decoction produced significant antinociceptive activity in all analgesia animal models used. The antinociceptive effect exhibited by the decoction in the formalin test was reversed by the systemic administration of naloxone, N(ω)-L-nitro-arginine methyl ester or glibenclamide. In contrast, theophylline did not reverse this effect. Nauclea latifolia (antinociceptive doses) did not exhibit a significant effect on motor coordination of the mice in Rota-rod performance. Nauclea latifolia protected mice against bicuculline-induced behavioral excitation. DISCUSSION AND
conclusionOverall, these results demonstrate that the central and peripheral effects of Nauclea latifolia root decoction might partially or wholly be due to the stimulation of peripheric opioid receptors through the action of the nitric oxide/cyclic monophosphate guanosin/triphosphate adenosine (NO/cGMP/ATP)-sensitive- K(+) channel pathway and/or facilitation of the GABAergic transmission.
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