ArticleMolecular pharmaceutics2010
Internalization of p53(14-29) peptide amphiphiles and subsequent endosomal disruption results in SJSA-1 cell death.
Article in Molecular pharmaceutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Extracellular Vesicles as Precision Delivery Systems for Biopharmaceuticals: Innovations, Challenges, and Therapeutic Potential.Pharmaceutics · 2025Review
- Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins.Advanced healthcare materials · 2022Review
- Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release.Materials (Basel, Switzerland) · 2019Article
- MiR-193a regulates chemoresistance of human osteosarcoma cells via repression of IRS2.Journal of bone oncology · 2019Article
- Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives.Molecules (Basel, Switzerland) · 2019Review
- Shape Effects of Peptide Amphiphile Micelles for Targeting Monocytes.Molecules (Basel, Switzerland) · 2018Article
- Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation.Bioconjugate chemistry · 2017Article
- The miR-34a-5p promotes the multi-chemoresistance of osteosarcoma via repression of the AGTR1 gene.BMC cancer · 2017Article
- Modular Peptide Amphiphile Micelles Improving an Antibody-Mediated Immune Response to Group A Streptococcus.ACS biomaterials science & engineering · 2017Article
- Peptide amphiphile micelles self-adjuvant group A streptococcal vaccination.The AAPS journal · 2015Article
- Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.Journal of materials chemistry. B · 2014Article
- The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles.PloS one · 2013Article
- Self-assembling peptide scaffolds for regenerative medicine.Chemical communications (Cambridge, England) · 2012Review
- De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly.Nano letters · 2011Article
- Materials from peptide assembly: towards the treatment of cancer and transmittable disease.Current opinion in chemical biology · 2011Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In vivo peptide inhibition of tumor suppressor p53 binding to the protein MDM2 is hampered by inefficient delivery of the peptide. Our approach to couple a hydrophobic lipid-like tail on the inhibitory peptide p53(14-29) allowed its intracellular delivery in vitro, in a panel of different cell lines. The constructed chimeric molecules, termed peptide amphiphiles, further self-assembled into supramolecular structures, identified as elongated wormlike micelles. Internalization of peptides occurred following micelle disassembly, partly via clathrin-mediated endocytosis of monomers. Incubation of SJSA-1 cells in hypertonic culture media, aimed to disrupt endocytic vesicles, resulted in peptide amphiphile-mediated cell death. Our results provide the basis for the construction of novel therapeutic supramolecular nanoparticles and suggest hydrophobic modification of peptides as a promising strategy for enhancing delivery of impermeable peptides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.