ReviewEuropean journal of applied physiology2011
Slow VO₂ kinetics during moderate-intensity exercise as markers of lower metabolic stability and lower exercise tolerance.
Review in European journal of applied physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Wet, volatile, and dry biomarkers of exercise-induced muscle fatigue.BMC musculoskeletal disorders · 2016Pooled it
- Cocoa-flavanols enhance moderate-intensity pulmonaryEuropean journal of applied physiology · 2021Trial
- Mechanisms of Attenuation of Pulmonary V'O2 Slow Component in Humans after Prolonged Endurance Training.PloS one · 2016Trial
- Observational
- Effect of hypoxia on muscle activation at equivalent absolute and relative intensity during incremental and constant load exercise to task failure.Experimental physiology · 2026Article
- Rapid method to identify the boundary speed for metabolic stability from race performances.Open access journal of sports medicine · 2026Article
- Development of a standardized single-session cardiopulmonary exercise test for combined assessment of peak oxygen uptake and on/off-kinetics.Experimental physiology · 2025Article
- Quantifying altered oxygen kinetics and reducing metabolic test times for children with cerebral palsy: a dual-exponential Bayesian modeling approach.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Article
- No sex differences in oxygen uptake or extraction kinetics in the moderate or heavy exercise intensity domains.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- How Priming Exercise Affects Oxygen Uptake Kinetics: From Underpinning Mechanisms to Endurance Performance.Sports medicine (Auckland, N.Z.) · 2023Review
- Interaction of Factors Determining Critical Power.Sports medicine (Auckland, N.Z.) · 2023Review
- The Effect of Endurance Training on Pulmonary V˙OInternational journal of environmental research and public health · 2022Article
- Oxygen uptake kinetics and ventilatory and metabolic parameters do not differ between moderate-intensity front crawl and breaststroke swimming.Physiological reports · 2022Article
- Walking endurance, muscle oxygen extraction, and perceived fatigability after overground locomotor training in incomplete spinal cord injury: A pilot study.The journal of spinal cord medicine · 2022Article
- Bioenergetic Mechanisms Linking V˙O2 Kinetics and Exercise Tolerance.Exercise and sport sciences reviews · 2021Article
- Anaerobic Speed/Power Reserve and Sport Performance: Scientific Basis, Current Applications and Future Directions.Sports medicine (Auckland, N.Z.) · 2021Article
- Measures of excessPilot and feasibility studies · 2021Article
- Oxygen uptake on-kinetics before and after aerobic exercise training in individuals with traumatic brain injury.Disability and rehabilitation · 2019Article
- Impact of 60 days of 6° head down tilt bed rest on muscular oxygen uptake and heart rate kinetics: efficacy of a reactive sledge jump countermeasure.European journal of applied physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
An analysis of previously published data obtained by our group on patients characterized by markedly slower pulmonary VO₂ kinetics (heart transplant recipients, patients with mitochondrial myopathies, patients with McArdle disease) was carried out in order to suggest that slow VO₂ kinetics should not be considered the direct cause, but rather a marker, of impaired exercise tolerance. For a given ATP turnover rate, faster (or slower) VO₂ kinetics are associated with smaller (or greater) muscle [PCr] decreases. The latter, however, should not be taken per se responsible for the higher (or lower) exercise tolerance, but should be considered within the general concept of "metabolic stability". Good muscle metabolic stability at a given ATP turnover rate (~power output) is associated with relatively smaller decreases, compared to rest, in [PCr] and in the Gibbs free energy of ATP hydrolysis, as well as with relatively smaller increases in [Pi], [ADP(free)], [AMP(free)], and [IMP(free)], metabolites directly related to fatigue. Disturbances in muscle metabolic stability can affect muscle function in various ways, whereas good metabolic stability is associated with less fatigue and higher exercise tolerance. Smaller [PCr] decreases, however, are strictly associated with a faster VO₂ kinetics. Thus, faster VO₂ kinetics may simply be an "epiphenomenon" of a relatively higher metabolic stability, which would then represent the relevant variable in terms of fatigue and exercise tolerance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.