ArticleImmunogenetics2010
MHC class I and MHC class II DRB gene variability in wild and captive Bengal tigers (Panthera tigris tigris).
Article in Immunogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
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- Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids.Frontiers in genetics · 2022Review
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- Evolution of major histocompatibility complex class I genes in the sableEcology and evolution · 2020Article
- Evolution of MHC class I genes in Eurasian badgers, genus Meles (Carnivora, Mustelidae).Heredity · 2019Article
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- Retention of functional variation despite extreme genomic erosion: MHC allelic repertoires in the Lynx genus.BMC evolutionary biology · 2017Article
- Egernia stokesii (gidgee skink) MHC I positively selected sites lack concordance with HLA peptide binding regions.Immunogenetics · 2017Article
- PCR Strategies for Complete Allele Calling in Multigene Families Using High-Throughput Sequencing Approaches.PloS one · 2016Article
- Patterns of genetic differentiation at MHC class I genes and microsatellites identify conservation units in the giant panda.BMC evolutionary biology · 2013Article
- Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K.Immunogenetics · 2013Article
- Living on the edge: how philopatry maintains adaptive potential.Proceedings. Biological sciences · 2013Article
- Domestication does not narrow MHC diversity in Sus scrofa.Immunogenetics · 2013Article
- Balancing selection and genetic drift at major histocompatibility complex class II genes in isolated populations of golden snub-nosed monkey (Rhinopithecus roxellana).BMC evolutionary biology · 2012Article
- Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited.Tissue antigens · 2012Article
- Can balancing selection on MHC loci counteract genetic drift in small fragmented populations of black grouse?Ecology and evolution · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bengal tigers are highly endangered and knowledge on adaptive genetic variation can be essential for efficient conservation and management. Here we present the first assessment of allelic variation in major histocompatibility complex (MHC) class I and MHC class II DRB genes for wild and captive tigers from India. We amplified, cloned, and sequenced alpha-1 and alpha-2 domain of MHC class I and beta-1 domain of MHC class II DRB genes in 16 tiger specimens of different geographic origin. We detected high variability in peptide-binding sites, presumably resulting from positive selection. Tigers exhibit a low number of MHC DRB alleles, similar to other endangered big cats. Our initial assessment-admittedly with limited geographic coverage and sample size-did not reveal significant differences between captive and wild tigers with regard to MHC variability. In addition, we successfully amplified MHC DRB alleles from scat samples. Our characterization of tiger MHC alleles forms a basis for further in-depth analyses of MHC variability in this illustrative threatened mammal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.