Trial reportInternational urogynecology journal2011
Intrasphincteric injections of autologous muscular cells in women with refractory stress urinary incontinence: a prospective study.
Trial report in International urogynecology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Autologous regenerative cell therapy for female stress urinary incontinence: a systematic review and meta-analysis of clinical outcomes.Frontiers in medicine · 2026Pooled it
- Urethral injection therapy for urinary incontinence in women.The Cochrane database of systematic reviews · 2017Pooled it
- Implantation of Autologous Skeletal Muscle-Derived Cells Combined with Electrical Stimulation in Patients with Stress Urinary Incontinence.International urogynecology journal · 2025Trial
- Transurethral injection of autologous muscle precursor cells for treatment of female stress urinary incontinence: a prospective phase I clinical trial.International urogynecology journal · 2023Trial
- A double-blind, randomized, placebo-controlled clinical trial evaluating the safety and efficacy of autologous muscle derived cells in female subjects with stress urinary incontinence.International urology and nephrology · 2018Trial
- Post-Treatment Response and Safety of Stem Cell-Based Urethral Injection Therapy for Female Stress Urinary Incontinence: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Human Muscle-Derived Cells Injected into Acute and Chronic Muscle Injuries Engraft and Support Regenerative Markers.Bioengineering (Basel, Switzerland) · 2026Article
- Progress on cell therapy for skeletal muscle disorders.Advanced drug delivery reviews · 2026Review
- Improved Sphincter Muscle Regeneration by Myoblasts fromMedical sciences (Basel, Switzerland) · 2026Article
- Cell Therapy in the Treatment of Female Stress Urinary Incontinence: Current Status and Future Proposals.Life (Basel, Switzerland) · 2024Review
- Bioprocessing Considerations towards the Manufacturing of Therapeutic Skeletal and Smooth Muscle Cells.Bioengineering (Basel, Switzerland) · 2023Review
- Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction.Cell & bioscience · 2023Review
- Treating and Managing Urinary Incontinence: Evolving and Potential Multicomponent Medical and Lifestyle Interventions.Research and reports in urology · 2023Review
- Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence.NPJ Regenerative medicine · 2022Article
- Current status of stem cell treatments and innovative approaches for stress urinary incontinence.Frontiers in medicine · 2022Review
- Treatment of Stress Urinary Incontinence with Muscle Stem Cells and Stem Cell Components: Chances, Challenges and Future Prospects.International journal of molecular sciences · 2021Review
- Contemporary application of autologous muscle-derived cells for urinary sphincter regeneration.World journal of urology · 2020Review
- Status, challenges, and future prospects of stem cell therapy in pelvic floor disorders.World journal of clinical cases · 2020Review
- Stem cell applications in regenerative medicine for stress urinary incontinence: A review of effectiveness based on clinical trials.Arab journal of urology · 2020Review
- Regenerative medicine and injection therapies in stress urinary incontinence.Nature reviews. Urology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisCell therapy for stress urinary incontinence (SUI) management has been experienced with encouraging results.
methodsWe conducted an open prospective study on 12 women presenting severe SUI with fixed urethra, after previous failed surgical management. Patients underwent intrasphincteric injections of autologous progenitor muscular cells isolated from a biopsy of deltoid muscle. Primary endpoint focused on safety (measurement of Q(max) variation after 3 months). Secondary endpoints assessed side effects and efficacy.
resultsNo variation was diagnosed on Q(max) measurements. Efficacy data show that three of 12 patients are dry at 12 months, seven other patients are improved on pad test but not on voiding diary, and two patients were slightly worsened by the procedure. Quality of life was improved in half of patients.
conclusionsCell therapy for severe multioperated cases of SUI is a mini-invasive, feasible, and safe procedure that can improve urinary condition in as a second line therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.