ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2011
High serum total cholesterol is a long-term cause of osteoporotic fracture.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The interplay between circulating high-density lipoprotein, age and fracture risk: a new cohort study and systematic meta-analysis.GeroScience · 2023Pooled it
- Association of Coffee and Tea Intake with Bone Mineral Density and Hip Fracture: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis.Journal of bone and mineral metabolism · 2021Pooled it
- Clinical Manifestations and Risk Factors of Osteoporosis in Patients with Type 2 Diabetes Mellitus.Journal of inflammation research · 2026Article
- The impact of childhood obesity on different fracture sites.Scientific reports · 2025Article
- Lipid metabolites are associated with the risk of osteoporotic fractures.Scientific reports · 2024Article
- The role of autophagy/lipophagy in the response of osteoblastic cells to hyperlipidemia (Review).Experimental and therapeutic medicine · 2024Review
- Cardiometabolic index is associated with increased bone mineral density: a population-based cross-sectional study.Frontiers in public health · 2024Article
- Correlation between Blood Lipid Level and Osteoporosis in Older Adults with Type 2 Diabetes Mellitus-A Retrospective Study Based on Inpatients in Beijing, China.Biomolecules · 2023Article
- Total Cholesterol Variability and the Risk of Osteoporotic Fractures: A Nationwide Population-Based Cohort Study.Journal of personalized medicine · 2023Article
- A negative association between total cholesterol and bone mineral density in US adult women.Frontiers in nutrition · 2022Article
- A retrospective study of end-stage kidney disease patients on maintenance hemodialysis with renal osteodystrophy-associated fragility fractures.BMC nephrology · 2021Article
- Metabolic factors and hip fracture risk in a large Austrian cohort study.Bone reports · 2020Article
- Effects of lipid metabolism on mouse incisor dentinogenesis.Scientific reports · 2020Article
- Triglyceride Can Predict the Discordance between QCT and DXA Screening for BMD in Old Female Patients.Disease markers · 2020Article
- A community-based study of the relationship between calcaneal bone mineral density and systemic parameters of blood glucose and lipids.Medicine · 2019Observational
- Modulation of Bone and Marrow Niche by Cholesterol.Nutrients · 2019Review
- Suppression Effect of Astaxanthin on Osteoclast Formation In Vitro and Bone Loss In Vivo.International journal of molecular sciences · 2018Article
- Association between Serum Cholesterol Level and Osteoporotic Fractures.Frontiers in endocrinology · 2018Article
- Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes.Frontiers in endocrinology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryRisk factors for osteoporotic fractures were evaluated in 1,396 men and women for a period of 20 years. Serum total cholesterol was found to be an independent osteoporotic fracture risk factor whose predictive power improves with time.
introductionThe purpose of this study was to evaluate long-term risk factors for osteoporotic fracture.
methodsA population random sample of men and women aged 25-64 years (the Gothenburg WHO MONICA project, N = 1,396, 53% women) was studied prospectively. The 1985 baseline examination recorded physical activity at work and during leisure time, psychological stress, smoking habits, coffee consumption, BMI, waist/hip ratio, blood pressure, total, HDL and LDL cholesterol, triglycerides, and fibrinogen. Osteoporotic fractures over a period of 20 years were retrieved from the Gothenburg hospital registers. Poisson regression was used to analyze the predictive power for osteoporotic fracture of each risk factor.
resultsA total number of 258 osteoporotic fractures occurred in 143 participants (10.2%). As expected, we found that previous fracture, smoking, coffee consumption, and lower BMI each increase the risk for osteoporotic fracture independently of age and sex. More unexpectedly, we found that the gradient of risk of serum total cholesterol to predict osteoporotic fracture significantly increases over time (p = 0.0377).
conclusionsSerum total cholesterol is an independent osteoporotic fracture risk factor whose predictive power improves with time. High serum total cholesterol is a long-term cause of osteoporotic fracture.
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