ArticleEuropean journal of epidemiology2011
Risk factors for otitis media in children with special emphasis on the role of colonization with bacterial airway pathogens: the Generation R study.
Article in European journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Prevalence ofInterdisciplinary perspectives on infectious diseases · 2022Article
- Association between nasal and nasopharyngeal bacterial colonization in early life and eczema phenotypes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Article
- Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life.Nature communications · 2019Article
- Article
- The Generation R Study: design and cohort update 2017.European journal of epidemiology · 2016Article
- Ear Infection and Its Associated Risk Factors in First Nations and Rural School-Aged Canadian Children.International journal of pediatrics · 2016Article
- Acute otitis media in children-current treatment and prevention.Current infectious disease reports · 2015Article
- Correlation of nasopharyngeal cultures prior to and at onset of acute otitis media with middle ear fluid cultures.BMC infectious diseases · 2014Article
- The Generation R Study: Biobank update 2015.European journal of epidemiology · 2014Article
- Incidence and clinical presentation of acute otitis media in children aged <6 years in European medical practices.Epidemiology and infection · 2014Observational
- Article
- Panel 5: Microbiology and immunology panel.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2013Review
- The Generation R Study: design and cohort update 2012.European journal of epidemiology · 2012Article
- Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media.PloS one · 2012Article
- Fetal and infant origins of asthma.European journal of epidemiology · 2012Review
- Breastfeeding and otitis media: a review of recent evidence.Current allergy and asthma reports · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute otitis media is the most frequent diagnosis in children visiting physicians' offices. Risk factors for otitis media have been widely studied. Yet, the correlation between bacterial carriage and the development of otitis media is not entirely clear. Our aim was to study in a population-based prospective cohort the risk factors for otitis media in the second year of life with special emphasis on the role of colonization with Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. The study was embedded in the Generation R Study. Data on risk factors and doctor-diagnosed otitis media were obtained by midwives, hospital registries and postal questionnaires in the whole cohort (n = 7,295). Nasopharyngeal swabs were obtained at the age of 1.5, 6 and 14 months in the focus cohort (n = 1,079). Of these children, 2,515 (47.2%) suffered at least one period of otitis media in their second year of life. The occurrence of otitis media during the follow-up period in the first 6 months of life and between 6 and 12 months of age was associated with the risk of otitis media in the second year of life (aOR, 1.83 95% CI 1.24-2.71 and aOR 2.72, 95% CI 2.18-3.38, respectively). Having siblings was associated with an increased risk for otitis media in the second year of life (aOR 1.42, 95% CI 1.13-1.79). No associations were found between bacterial carriage in the first year of life and otitis media in the second year of life. In our study, otitis media in the first year of life is an independent risk factor for otitis media in the second year of life. Surprisingly, bacterial carriage in the first year of life did not add to this risk. Moreover, no association was observed between bacterial carriage in the first year of life and otitis in the second year of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.