ArticleEuropean radiology2011
Fetal liver iron overload: the role of MR imaging.
Article in European radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Intrauterine blood transfusion causes dose- and time-dependent signal alterations in the liver and the spleen on fetal magnetic resonance imaging.European radiology · 2025Article
- Standardised and structured reporting in fetal magnetic resonance imaging: recommendations from the Fetal Task Force of the European Society of Paediatric Radiology.Pediatric radiology · 2024Review
- Magnetic resonance imaging of fetal abdominal pathology: a complementary tool to prenatal ultrasound.Pediatric radiology · 2023Article
- The MRI spectrum of congenital cytomegalovirus infection.Prenatal diagnosis · 2020Review
- Evaluation of the fetal abdomen by magnetic resonance imaging. Part 1: malformations of the abdominal cavity.Radiologia brasileiraArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the potential role of MR imaging in the diagnosis of fetal liver iron overload.
methodsWe reviewed seven cases of abnormal liver signal in fetuses referred to MR imaging in a context of suspected congenital infection (n = 2), digestive tract anomalies (n = 3) and hydrops fetalis (n = 2). The average GA of the fetuses was 31 weeks. The antenatal diagnoses were compared with histological data (n = 6) and postnatal work-up (n = 1).
resultsMagnetic resonance imaging demonstrated unexpected abnormal fetal liver signal suggestive of iron overload in all cases. The iron overload was confirmed on postnatal biopsy (n = 2) and fetopathology (n = 4). The final diagnosis was hepatic hemosiderosis (haemolytic anaemia (n = 2) and syndromal anomalies (n = 2)) and congenital haemochromatosis (n = 3). In all cases, the liver appeared normal on US.
conclusionsMagnetic resonance is the only imaging technique able to demonstrate liver iron overload in utero. Yet, the study outlines the fundamental role of MR imaging in cases of congenital haemochromatosis. The antenatal diagnosis of such a condition may prompt ante-(in the case of recurrence) or neonatal treatment, which might improve the prognosis.
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