ArticleEuropean journal of nuclear medicine and molecular imaging2010
Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging.
Article in European journal of nuclear medicine and molecular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 30 citations in OpenAlex.
- Quantification of Myocardial Perfusion Reserve Using Dynamic SPECT Imaging in Humans: A Feasibility Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Trial
- Parathyroid hormone-PTH1R signaling in cardiovascular disease and homeostasis.Trends in endocrinology and metabolism: TEM · 2024Review
- Functional significance of intermediate coronary stenosis in patients with single-vessel coronary artery disease: A comparison of dynamic SPECT coronary flow reserve with intracoronary pressure-derived fractional flow reserve (FFR).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Primary Hyperparathyroidism: A Narrative Review of Diagnosis and Medical Management.Journal of clinical medicine · 2021Review
- Comparison of coronary flow reserve estimated by dynamic radionuclide SPECT and multi-detector x-ray CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop.The Journal of clinical endocrinology and metabolism · 2014Article
- Article
- 1,25-Dihydroxy vitamin D and coronary microvascular function.European journal of nuclear medicine and molecular imaging · 2013Article
- Cardiovascular diseases in older patients with osteoporotic hip fracture: prevalence, disturbances in mineral and bone metabolism, and bidirectional links.Clinical interventions in aging · 2013Article
- Nontraditional manifestations of primary hyperparathyroidism.Journal of clinical densitometry : the official journal of the International Society for Clinical DensitometryReview
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12 authors at 2 institutions in 1 country.
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Abstract
purposeThe mechanisms underlying increased cardiovascular risk in primary hyperparathyroidism (pHPT) have not been fully defined. Recently, this issue has become the subject of renewed interest due to the increasing evidence that the endothelium and vascular wall are targets for parathyroid hormone (PTH). The aim of this study was to measure regional coronary flow reserve (CFR) to determine whether the vascular damage induced by pHPT extends to affect the coronary microvascular function.
methodsA total of 22 pHPT patients without a history of coronary artery disease and 7 age-matched control subjects were recruited. Dipyridamole myocardial blood flow (MBF) was assessed using 99mTc-sestamibi by measuring first-transit counts in the pulmonary artery and myocardial count rate from G-SPECT images. Baseline MBF was estimated 2 h later according to the same procedure. Regional CFR was defined as the ratio between dipyridamole and baseline MBF using a 17-segment left ventricular model.
resultsThree pHPT patients showed reversible perfusion defects and were excluded from the analysis. In the remaining 19, CFR was significantly lower with respect to the control subjects (1.88±0.64 vs. 3.36±0.66, respectively; p<0.01). Moreover, patients studied for more than 28 months from pHPT diagnosis showed lower CFR values than the others (1.42±0.18 vs. 2.25±0.64, respectively; p<0.01). Consequently, the time from diagnosis to the nuclear study showed a reasonable correlation with the degree of CFR impairment (Spearman's rho -0.667, p<0.02).
conclusionpHPT is associated with a significant dysfunction of the coronary microcirculation. This disorder might contribute to the high cardiovascular risk of conditions characterized by chronic elevations in serum PTH levels.
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