ReviewCurrent diabetes reports2010
The genetics of insulin resistance: Where's Waldo?
Review in Current diabetes reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Mini-review: Mitochondrial DNA methylation in type 2 diabetes and obesity.Frontiers in endocrinology · 2022Review
- Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance.International journal of molecular sciences · 2021Review
- A Replication Study Identified Seven SNPs Associated with Quantitative Traits of Type 2 Diabetes among Chinese Population in A Cross-Sectional Study.International journal of environmental research and public health · 2020Article
- Classification of Type 2 Diabetes Genetic Variants and a Novel Genetic Risk Score Association With Insulin Clearance.The Journal of clinical endocrinology and metabolism · 2020Article
- Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma.Oncotarget · 2017Review
- Article
- The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.Molecular & cellular proteomics : MCP · 2015Article
- Selection of reference genes for expression analyses in liver of rats with impaired glucose metabolism.International journal of clinical and experimental pathology · 2015Article
- Article
- Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog.Obesity (Silver Spring, Md.) · 2014Article
- Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility.World journal of diabetes · 2014Review
- Epigenetics of insulin resistance: an emerging field in translational medicine.Current diabetes reports · 2013Review
- Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance.The Journal of nutrition · 2013Article
- Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population.Endocrine · 2013Article
- Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance.PloS one · 2013Article
- Article
- T2DM: Why Epigenetics?Journal of nutrition and metabolism · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The physiologic hallmarks of type 2 diabetes are insulin resistance in hepatic and peripheral tissues and pancreatic β-cell dysfunction. Thus, genetic loci underlying susceptibility to type 2 diabetes are likely to map to one of these endophenotypes. Genome-wide association studies have now identified up to 38 susceptibility loci for type 2 diabetes and a number of other loci underlying variation in type 2 diabetes-related quantitative traits. The majority are of unknown biology or map to pancreatic β-cell dysfunction. A seemingly disproportionate minority map to insulin resistance. We briefly discuss the known insulin resistance loci identified from genome-wide association, and then discuss reasons why additional insulin resistance loci have not been identified. We present alternative views that may partly explain the apparent dearth of insulin resistance loci contributing to genetic susceptibility to type 2 diabetes, rather than focus on traditional issues such as study design and sampling, which have been addressed elsewhere.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.