ArticleEnvironmental science and pollution research international2011
The endocrine disrupting potential of sediments from the Upper Danube River (Germany) as revealed by in vitro bioassays and chemical analysis.
Article in Environmental science and pollution research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 73 citations in OpenAlex.
- Ecotoxicological evaluation of surface waters in Northern Namibia.Environmental monitoring and assessment · 2024Article
- Embryo/larval toxicity and transcriptional effects in zebrafish (Danio rerio) exposed to endocrine active riverbed sediments.Environmental science and pollution research international · 2020Article
- Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts.Environmental sciences Europe · 2017Article
- Changing agricultural practices: potential consequences to aquatic organisms.Environmental monitoring and assessment · 2016Article
- Emerging and priority contaminants with endocrine active potentials in sediments and fish from the River Po (Italy).Environmental science and pollution research international · 2015Article
- Screening of multiple hormonal activities in water and sediment from the river Nile, Egypt, using in vitro bioassay and gonadal histology.Environmental monitoring and assessment · 2015Article
- Aryl hydrocarbon receptor (AhR) inducers and estrogen receptor (ER) activities in surface sediments of Three Gorges Reservoir, China evaluated with in vitro cell bioassays.Environmental science and pollution research international · 2014Article
- Article
- Effects of multiwalled carbon nanotubes and triclocarban on several eukaryotic cell lines: elucidating cytotoxicity, endocrine disruption, and reactive oxygen species generation.Nanoscale research letters · 2014Article
- Genetically modified whole-cell bioreporters for environmental assessment.Ecological indicators · 2013Article
- Effect directed analysis and mixture effects of estrogenic compounds in a sediment of the river Elbe.Environmental science and pollution research international · 2012Article
- Occurrence and biodegradation of nonylphenol in the environment.International journal of molecular sciences · 2012Review
- Effect-directed analysis (EDA) in aquatic ecotoxicology: state of the art and future challenges.Environmental science and pollution research international · 2009Article
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Authors and funding
8 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe present study was part of a comprehensive weight-of-evidence approach with the goal of identifying potential causes for the declines in fish populations, which have been observed during the past decades in the Upper Danube River.
methodsThe specific goal was the investigation of the endocrine disrupting potential of sediment extracts from different sites along the Danube River. Parallel to the identification and quantification of target estrogens, two in vitro bioassays were employed to assess the estrogenic potential (yeast estrogen screen, YES) of the sediment samples and to evaluate their effects on the production of testosterone (T) and E2 (H295R Steroidogenesis Assay). Using a potency balance approach, the contribution of the measured compounds (Chem-EEQs) to the total endocrine activity measured by the YES (YES-EEQs) was calculated. RESULTS AND DISCUSSION: Of the nine sediment extracts tested five extracts exhibited significant estrogenic activities in the YES, which suggested the presence of ER agonists in these samples. The xenoestrogens nonylphenol (NP) and bisphenol A (BPA) and the natural estrogen estrone (E1) were detected while concentrations of 17β-estradiol (E2) and ethinylestradiol (EE2) were less than their respective limits of quantification in all sediment extracts. A comparison of the measured YES-EEQs and the calculated Chem-EEQs revealed that as much as 6% of estrogenic activity in extracts of most sediments could be explained by two xeno- and one natural estrogen. Exposure of H295R cells to sediment extracts from four different locations in the Danube River resulted in significantly increased concentrations of E2, but only slight inhibition of T synthesis. Furthermore, application of the H295R Steroidogenesis Assay provided evidence for endocrine disrupting potencies in sediment samples from the Upper Danube River, some of which were not detectable with the YES. In conclusion, differential endocrine activities were associated with several sediments from the Upper Danube River. Further investigations will have to show whether the observed activities are of biological relevance with regard to declines in fish populations in the Upper Danube River.
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