ReviewHeart failure reviews2011
Evidence for impaired vagus nerve activity in heart failure.
Review in Heart failure reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Trial
- The Vagal Link: Autonomic Nervous System Dysfunction in Cardiac Amyloidosis.Journal of clinical medicine · 2025Review
- Autonomic control of the pulmonary circulation: Implications for pulmonary hypertension.Experimental physiology · 2025Review
- Treating heart failure by targeting the vagus nerve.Heart failure reviews · 2024Review
- The promise of cardiac neuromodulation: can computational modelling bridge the gap?The Journal of physiology · 2023Article
- Physiological ischemic training improves cardiac function through the attenuation of cardiomyocyte apoptosis and the activation of the vagus nerve in chronic heart failure.Frontiers in neuroscience · 2023Article
- Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation?Frontiers in cardiovascular medicine · 2023Review
- Positivity resonance in long-term married couples: Multimodal characteristics and consequences for health and longevity.Journal of personality and social psychology · 2022Article
- Heart Rate Variability Biofeedback for Substance Use Disorder: Health Policy Implications.Policy insights from the behavioral and brain sciences · 2022Article
- Modern Approaches for the Treatment of Heart Failure: Recent Advances and Future Perspectives.Pharmaceutics · 2022Review
- Proteomics Reveals Long-Term Alterations in Signaling and Metabolic Pathways Following Both Myocardial Infarction and Chemically Induced Denervation.Neurochemical research · 2022Article
- Relationship of Cardiac Autonomic Modulation with Cardiovascular Parameters in Adults, According to Body Mass Index and Physical Activity.Journal of cardiovascular translational research · 2021Observational
- Electrical properties and synaptic transmission in mouse intracardiac ganglion neurons in situ.Physiological reports · 2021Article
- Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart.The journal of physiological sciences : JPS · 2021Article
- Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling.The Journal of biological chemistry · 2020Article
- Neuromodulation Therapy in Heart Failure: Combined Use of Drugs and Devices.The Journal of innovations in cardiac rhythm management · 2020Article
- Chronic vagal nerve stimulation has no effect on tachycardia-induced heart failure progression or excitation-contraction coupling.Physiological reports · 2020Article
- Investigating the Effects of Brainstem Neuronal Adaptation on Cardiovascular Homeostasis.Frontiers in neuroscience · 2020Article
- Cardiac Alternans: Mechanisms and Clinical Utility in Arrhythmia Prevention.Journal of the American Heart Association · 2019Review
- Augmented fear bradycardia in rats with heart failure.The journal of physiological sciences : JPS · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasympathetic control of the heart via the vagus nerve is the primary mechanism that regulates beat-to-beat control of heart rate. Additionally, the vagus nerve exerts significant effects at the AV node, as well as effects on both atrial and ventricular myocardium. Vagal control is abnormal in heart failure, occurring at early stages of left ventricular dysfunction, and this reduced vagal function is associated with worse outcomes in patients following myocardial infarction and with heart failure. While central control mechanisms are abnormal, one of the primary sites of attenuated vagal control is at the level of the parasympathetic ganglion. It remains to be seen whether or not preventing or treating abnormal vagal control of the heart improves prognosis.
Indexed as
Identifiers
20820912What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.