ArticleNanoscale2010
Intracellular trafficking of silicon particles and logic-embedded vectors.
Article in Nanoscale, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways.Pharmaceutics · 2021Article
- Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells.Cancers · 2020Article
- Heterogeneous Fenton Reaction Enabled Selective Colon Cancerous Cell Treatment.Scientific reports · 2018Article
- The challenges of oral drug delivery via nanocarriers.Drug delivery · 2018Review
- Trends towards Biomimicry in Theranostics.Nanomaterials (Basel, Switzerland) · 2018Review
- Tracking the Fate of Porous Silicon Nanoparticles Delivering a Peptide Payload by Intrinsic Photoluminescence Lifetime.Advanced materials (Deerfield Beach, Fla.) · 2018Article
- A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells.Pharmacological research · 2016Article
- A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics.European journal of heart failure · 2016Article
- Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases.Cancer research · 2016Article
- The effect of multistage nanovector targeting of VEGFR2 positive tumor endothelia on cell adhesion and local payload accumulation.Biomaterials · 2014Article
- Oxidation-Induced Trapping of Drugs in Porous Silicon Microparticles.Chemistry of materials : a publication of the American Chemical Society · 2014Article
- Cellular communication via nanoparticle-transporting biovesicles.Nanomedicine (London, England) · 2014Article
- Characterization of Free and Porous Silicon-Encapsulated Superparamagnetic Iron Oxide Nanoparticles as Platforms for the Development of Theranostic Vaccines.Medical sciences (Basel, Switzerland) · 2014Article
- Evaluation of cell function upon nanovector internalization.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- Short and long term, in vitro and in vivo correlations of cellular and tissue responses to mesoporous silicon nanovectors.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- Silicon micro- and nanofabrication for medicine.Advanced healthcare materials · 2013Review
- Targeted fluoromagnetic nanoparticles for imaging of breast cancer mcf-7 cells.Advanced pharmaceutical bulletin · 2013Article
- Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions.Nature nanotechnology · 2013Article
- Inter-endothelial transport of microvectors using cellular shuttles and tunneling nanotubes.Small (Weinheim an der Bergstrasse, Germany) · 2012Article
- Dual-imaging enabled cancer-targeting nanoparticles.Advanced healthcare materials · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Mesoporous silicon particles show great promise for use in drug delivery and imaging applications as carriers for second-stage nanoparticles and higher order particles or therapeutics. Modulation of particle geometry, surface chemistry, and porosity allows silicon particles to be optimized for specific applications such as vascular targeting and avoidance of biological barriers commonly found between the site of drug injection and the final destination. In this study, the intracellular trafficking of unloaded carrier silicon particles and carrier particles loaded with secondary iron oxide nanoparticles was investigated. Following cellular uptake, membrane-encapsulated silicon particles migrated to the perinuclear region of the cell by a microtubule-driven mechanism. Surface charge, shape (spherical and hemispherical) and size (1.6 and 3.2 microm) of the particle did not alter the rate of migration. Maturation of the phagosome was associated with an increase in acidity and acquisition of markers of late endosomes and lysosomes. Cellular uptake of iron oxide nanoparticle-loaded silicon particles resulted in sorting of the particles and trafficking to unique destinations. The silicon carriers remained localized in phagosomes, while the second stage iron oxide nanoparticles were sorted into multi-vesicular bodies that dissociated from the phagosome into novel membrane-bound compartments. Release of iron from the cells may represent exocytosis of iron oxide nanoparticle-loaded vesicles. These results reinforce the concept of multi-functional nanocarriers, in which different particles are able to perform specific tasks, in order to deliver single- or multi-component payloads to specific sub-cellular compartments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.