Evidence map›Paper›PMID 20819928›Full record

ArticleThe Journal of experimental medicine2010

Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment.

Nathalie T Joncker, Nataliya Shifrin, Frédéric Delebecque, David H Raulet

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 241 citations in OpenAlex.

  1. Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Memory-like CD8Frontiers in immunology · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. LAG3 Marks Activated but Hyporesponsive NK Cells.European journal of immunology · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. An inference model gives insights into innate immune adaptation and repertoire diversity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nathalie T JonckerDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA.
Nataliya Shifrin
Frédéric Delebecque
David H Raulet
University of California, Berkeley · US

Funding

Role of MHC molecules in NK recognitionR01AI035021 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAULET, DAVID H · 1994 to 2008
$1.9M
Role of MHC Molecules in NK RecognitionR56AI035021 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAULET, DAVID H · 2010 to 2010
$266k
NIAID NIH HHS R01 AI035021NIAID NIH HHS R01AI35021NIAID NIH HHS R56 AI035021
6 · The paper itself

Abstract

Some mature natural killer (NK) cells cannot be inhibited by major histocompatibility complex (MHC) I molecules, either because they lack corresponding inhibitory receptors or because the host lacks the corresponding MHC I ligands for the receptors. Such NK cells nevertheless remain self-tolerant and exhibit a generalized hyporesponsiveness to stimulation through activating receptors. To address whether NK cell responsiveness is set only during the NK cell differentiation process, we transferred mature NK cells from wild-type (WT) to MHC I-deficient hosts or vice versa. Remarkably, mature responsive NK cells from WT mice became hyporesponsive after transfer to MHC I-deficient mice, whereas mature hyporesponsive NK cells from MHC I-deficient mice became responsive after transfer to WT mice. Altered responsiveness was evident among mature NK cells that had not divided in the recipient animals, indicating that the cells were mature before transfer and that alterations in activity did not require cell division. Furthermore, the percentages of NK cells expressing KLRG1, CD11b, CD27, and Ly49 receptors specific for H-2(b) were not markedly altered after transfer. Thus, the functional activity of mature NK cells can be reset when the cells are exposed to a changed MHC environment. These findings have important implications for how NK cell functions may be curtailed or enhanced in the context of disease.

Indexed as

Lymphocyte ActivationAnimalsCD11b AntigenCell DifferentiationCell DivisionH-2 AntigensHistocompatibility Antigens Class IKiller Cells, NaturalLectins, C-TypeMiceNK Cell Lectin-Like Receptor Subfamily AReceptors, ImmunologicSelf ToleranceTumor Necrosis Factor Receptor Superfamily, Member 7CD11b AntigenH-2 AntigensHistocompatibility Antigens Class IKlrg1 protein, mouseLectins, C-TypeNK Cell Lectin-Like Receptor Subfamily AReceptors, ImmunologicTumor Necrosis Factor Receptor Superfamily, Member 7

Identifiers

PMID20819928
PMCPMC2947079
OpenAlexW2165144791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.