Evidence map›Paper›PMID 20819896›Full record

ReviewPediatrics2010

Bisphenol A and related compounds in dental materials.

Abby F Fleisch, Perry E Sheffield, Courtney Chinn, Burton L Edelstein, Philip J Landrigan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  3. Clinical effectiveness of pit and fissure sealants in primary and permanent teeth of children and adolescents: an umbrella review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024
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  8. Pit and fissure sealants for preventing dental decay in permanent teeth.The Cochrane database of systematic reviews · 2017
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Abby F FleischDepartment of Medicine, Children's Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA. abby.fleisch@childrens.harvard.edu
Perry E Sheffield
Courtney Chinn
Burton L Edelstein
Philip J Landrigan

Funding

Research Training Program in Pediatric ExposomicsT32HD049311 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2007 to 2026
$7.4M
NICHD NIH HHS T32 HD049311
6 · The paper itself

Abstract

contextDental sealants and composite filling materials containing bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivatives can pose health risks attributable to their endocrine-disrupting, estrogenic properties.

objectivesTo systematically compile and critically evaluate the literature characterizing BPA content of dental materials; to assess BPA exposures from dental materials and potential health risks; and to develop evidence-based guidance for reducing BPA exposures while promoting oral health.

methodsThe extant toxicological literature and material safety data sheets were used as data sources.

resultsBPA is released from dental resins through salivary enzymatic hydrolysis of BPA derivatives, and BPA is detectable in saliva for up to 3 hours after resin placement. The quantity and duration of systemic BPA absorption is not clear from the available data. Dental products containing the bisphenol A derivative glycidyl dimethacrylate (bis-GMA) are less likely to be hydrolyzed to BPA and have less estrogenicity than those containing bisphenol A dimethacrylate (bis-DMA). Most other BPA derivatives used in dental materials have not been evaluated for estrogenicity. BPA exposure can be reduced by cleaning and rinsing surfaces of sealants and composites immediately after placement.

conclusionsOn the basis of the proven benefits of resin-based dental materials and the brevity of BPA exposure, we recommend continued use with strict adherence to precautionary application techniques. Use of these materials should be minimized during pregnancy whenever possible. Manufacturers should be required to report complete information on the chemical composition of dental products and encouraged to develop materials with less estrogenic potential.

Indexed as

Benzhydryl CompoundsBisphenol A CompoundsDental MaterialsHumansPhenolsPit and Fissure SealantsResins, SyntheticBenzhydryl Compoundsbisphenol ABisphenol A CompoundsDental MaterialsPhenolsPit and Fissure SealantsResins, Synthetic

Identifiers

PMID20819896
PMCPMC4139922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.