ArticleBMJ (Clinical research ed.)2010
Isoniazid resistance and death in patients with tuberculous meningitis: retrospective cohort study.
Article in BMJ (Clinical research ed.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Microbiological diagnosis and mortality of tuberculosis meningitis: Systematic review and meta-analysis.PloS one · 2023Pooled it
- Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2019Guideline
- Isoniazid-resistant tuberculosis in children: a systematic review.The Pediatric infectious disease journal · 2013Pooled it
- Clinical Outcomes of Patients With Drug-Resistant Tuberculous Meningitis Treated With an Intensified Antituberculosis Regimen.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Trial
- Influence of antituberculosis drug resistance and Mycobacterium tuberculosis lineage on outcome in HIV-associated tuberculous meningitis.Antimicrobial agents and chemotherapy · 2012Trial
- Are We Capable of Unveiling the Missed Epidemic of Isoniazid-resistant Tuberculosis?Annals of the American Thoracic Society · 2024Article
- Clinical features, resistance patterns and treatment outcomes of drug-resistant extra-pulmonary tuberculosis: A scoping review.Journal of clinical tuberculosis and other mycobacterial diseases · 2023Article
- Article
- Clinicopathology conference: 41-year-old woman with chronic relapsing meningitis.Annals of neurology · 2019Article
- Isoniazid Monoresistance and Rate of Culture Conversion among Patients in the State of Georgia with Confirmed Tuberculosis, 2009-2014.Annals of the American Thoracic Society · 2018Article
- Tuberculous Meningitis in Children and Adults: New Insights for an Ancient Foe.Current neurology and neuroscience reports · 2017Review
- Tuberculosis Meningitis.Current infectious disease reports · 2017Review
- Long-term Mortality of Patients With Tuberculous Meningitis in New York City: A Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Isoniazid-resistant tuberculosis: a cause for concern?The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Review
- Traditional and syndromic surveillance of infectious diseases and pathogens.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2016Review
- Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study.Annals of clinical microbiology and antimicrobials · 2015Article
- Real-Time Microbiology Laboratory Surveillance System to Detect Abnormal Events and Emerging Infections, Marseille, France.Emerging infectious diseases · 2015Article
- Prognostic factors of tuberculous meningitis: a single-center study.International journal of clinical and experimental medicine · 2015Article
- Major outcomes of patients with tuberculous meningitis on directly observed thrice a week regime.Annals of Indian Academy of Neurology · 2014Article
- First Use of Multiple Imputation with the National Tuberculosis Surveillance System.Epidemiology Research International · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether initial isoniazid resistance is associated with death during the treatment of tuberculous meningitis.
designRetrospective cohort study.
settingNational Tuberculosis Surveillance System at the Centers for Disease Control in the United States.
participantsPatients with a clinical diagnosis of tuberculous meningitis, reported to the National Tuberculosis Surveillance System between 1 January 1993 and 31 December 2005.
main outcome measureAll cause mortality during antituberculous treatment.
resultsBetween 1993 and 2005, 1896 patients had a clinical diagnosis of tuberculous meningitis and positive cultures from any site. In 123 (6%) of these patients, isoniazid resistance was present on initial susceptibility testing. The unadjusted association between initial isoniazid resistance and subsequent death among these 1896 patients did not reach statistical significance (odds ratio 1.38, 95% confidence interval 0.94 to 2.02). However, among 1614 patients with positive cerebrospinal fluid cultures, a significant unadjusted association was found between initial isoniazid resistance and subsequent death (odds ratio 1.61, 1.08 to 2.40). This association increased after adjustment for age, race, sex, and HIV status (odds ratio 2.07, 1.30 to 3.29).
conclusionsIsoniazid resistance on initial susceptibility testing was associated with subsequent death among cases of tuberculous meningitis with positive cerebrospinal fluid cultures. Randomised controlled trials are needed to evaluate the optimal empirical regimen for treating patients with tuberculous meningitis who are at high risk for both initial isoniazid resistance and poor clinical outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.