ArticleAnnals of the Royal College of Surgeons of England2010
Diverticular fistulation is associated with nicorandil usage.
Article in Annals of the Royal College of Surgeons of England, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Adverse event profiles of microscopic colitis in the Japanese Adverse Drug Event Report (JADER) database.Scientific reports · 2022Article
- Nicorandil-induced colovesical fistula in a patient with diverticular disease.Clinical case reports · 2021Article
- A Very Rare Case of Colosalpingeal Fistula Secondary to Diverticulitis: An Overview of Development, Clinical Features and Management.Medicina (Kaunas, Lithuania) · 2020Review
- Role of nicotinic acid and nicotinamide in nicorandil-induced ulcerations: from hypothesis to demonstration.International wound journal · 2015Article
- Medical management of chronic stable angina.Australian prescriber · 2015Review
- Nicorandil-induced colonic ulceration.BMJ case reports · 2015Article
- De novo rectovaginal fistulation and multisite ulceration as a consequence of nicorandil therapy.International journal of colorectal disease · 2014Article
- Nicorandil: from ulcer to fistula into adjacent organs.International wound journal · 2013Article
- Nicorandil ulcer: moves beyond the mucosa.Annals of the Royal College of Surgeons of England · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe observed that a number of patients presenting to our clinic with diverticular fistulation were taking nicorandil for angina. Recognised side effects of nicorandil include gastrointestinal and genital ulceration. The aim of our study was to determine whether nicorandil is an aetiological agent in diverticular fistulation. PATIENTS AND
methodsWe conducted a case-control study of patients with diverticular disease related enteric fistulae. Two patient groups were identified: a study group of patients with diverticular fistulae, and a control group with uncomplicated diverticular disease. The proportion of patients who had ever used nicorandil was compared between the two groups.
resultsA total of 153 case notes were analysed, 69 patients with fistulae and 84 control patients with uncomplicated diverticular disease. Female to male ratio in both groups was 2:1. The mean age was 71 years in the fistula group and 69 years in the control diverticular disease group (P = ns). Of those with colonic fistulae, 16% were taking nicorandil compared with 2% of the control group (odds ratio 7.8; 95% confidence interval 1.5-39.1; P = 0.008). There was no significant difference in rates of ischaemic heart disease between fistula and control groups.
conclusionsNicorandil is associated with fistula formation in diverticular disease.
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