ArticleTransplant international : official journal of the European Society for Organ Transplantation2011
Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine.
Article in Transplant international : official journal of the European Society for Organ Transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Pancreatic Islet Transplantation in Extrahepatic Sites: Evaluation of the Venous Sac in Large Mammal Models.Diabetes & metabolism journal · 2026Article
- Impact of oxygen and glucose availability on the viability and connectivity of islet cells: A computational study of reconstructed avascular human islets.PLoS computational biology · 2024Article
- Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells.Stem cell reviews and reports · 2022Article
- Generation of insulin-secreting organoids: a step toward engineering and transplanting the bioartificial pancreas.Transplant international : official journal of the European Society for Organ Transplantation · 2020Review
- Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device.Transplantation · 2015Article
- Chronic pancreatitis and primary sclerosing cholangitis--first report of intrahepatic autologous islet transplantation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Article
- Bioengineered sites for islet cell transplantation.Current diabetes reports · 2013Review
- Evaluation of a collagen-chitosan hydrogel for potential use as a pro-angiogenic site for islet transplantation.PloS one · 2013Article
- An isolated venous sac as a novel site for cell therapy in diabetes mellitus.Transplantation · 2012Article
- Imaging the islet graft by positron emission tomography.European journal of nuclear medicine and molecular imaging · 2012Review
- Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes.Transplant international : official journal of the European Society for Organ TransplantationArticle
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Authors and funding
5 authors.
Funding
Abstract
This study evaluated the potential of vascularized small intestinal segments for pancreatic islet transplantation. Islets isolated from Lewis rats were transplanted into diabetic syngeneic recipients. Segments of small intestine were prepared by denudation of the mucosal layer prior to implantation of pancreatic islets into the segments. Animal groups were established to determine engraftment, survival and function of islets transplanted into either intestinal segments or portal vein over up to 60 days. We found transplantation of functionally intact pancreatic islets into small intestinal segments was well tolerated. Transplanted islets were rapidly engrafted in intestinal segments as demonstrated vascularization and expression of insulin and glucagon throughout the 60-day duration of the studies. Transplantation of islets restored euglycemia in diabetic rats, which was similar to animals receiving islets intraportally. Moreover, animals treated with islet transplants showed normal responses to glucose challenges. Removal of graft-bearing intestinal segments led to recurrence of hyperglycemia indicating that transplanted islets were responsible for improved outcomes. Therefore, we concluded that vascularized intestinal segments supported reorganization, survival and function of transplanted islets with therapeutic efficacy in streptozotocin-treated diabetic rats. The approach described here will be appropriate for studying islet biogenesis, reorganization and function, including for cell therapy applications.
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