ArticleAging2010
Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis.
Article in Aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 59 citations in OpenAlex.
- Mild cognitive impairment and pre-frailty show distinct plasma multi-omic signatures: a cross-sectional study.GeroScience · 2026Article
- African Local Pig Genetic Resources in the Context of Climate Change Adaptation.Animals : an open access journal from MDPI · 2024Review
- Advanced Methodology for Rapid Isolation of Single Myofibers from Flexor Digitorum Brevis Muscle.Tissue engineering. Part C, Methods · 2023Article
- Alteration of STIM1/Orai1-Mediated SOCE in Skeletal Muscle: Impact in Genetic Muscle Diseases and Beyond.Cells · 2021Review
- Two Types of Mouse Models for Sarcopenia Research: Senescence Acceleration and Genetic Modification Models.Journal of bone metabolism · 2021Article
- Mouse models of sarcopenia: classification and evaluation.Journal of cachexia, sarcopenia and muscle · 2021Review
- MBNL1-Associated Mitochondrial Dysfunction and Apoptosis in C2C12 Myotubes and Mouse Skeletal Muscle.International journal of molecular sciences · 2020Article
- Genome Wide Assessment of Genetic Variation and Population Distinctiveness of the Pig Family in South Africa.Frontiers in genetics · 2020Article
- Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Deficiency of MTMR14 impairs male fertility in Mus musculus.PloS one · 2018Article
- Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C. elegans muscle.Journal of cachexia, sarcopenia and muscle · 2017Article
- Article
- Mice lacking myotubularin-related protein 14 show accelerated high-fat diet-induced lipid accumulation and inflammation.Journal of physiology and biochemistry · 2017Article
- Article
- Pathophysiological concepts in the congenital myopathies: blurring the boundaries, sharpening the focus.Brain : a journal of neurology · 2015Review
- Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner.Cell & bioscience · 2015Article
- Longevity, aging and rapamycin.Cellular and molecular life sciences : CMLS · 2014Review
- Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts.Molecular and cellular biochemistry · 2014Article
- Phosphoinositide substrates of myotubularin affect voltage-activated Ca²⁺ release in skeletal muscle.Pflugers Archiv : European journal of physiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
We have recently reported that a novel muscle-specific inositide phosphatase (MIP/MTMR14) plays a critical role in [Ca2+]i homeostasis through dephosphorylation of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol (3,5) bisphosphate (PI(3,5)P2). Loss of function mutations in MIP have been identified in human centronuclear myopathy. We developed a MIP knockout (MIPKO) animal model and found that MIPKO mice were more susceptible to exercise-induced muscle damage, a trademark of muscle functional changes in older subjects. We used wild-type (Wt) mice and MIPKO mice to elucidate the roles of MIP in muscle function during aging. We found MIP mRNA expression, MIP protein levels, and MIP phosphatase activity significantly decreased in old Wt mice. The mature MIPKO mice displayed phenotypes that closely resembled those seen in old Wt mice: i) decreased walking speed, ii) decreased treadmill activity, iii) decreased contractile force, and iv) decreased power generation, classical features of sarcopenia in rodents and humans. Defective Ca2+ homeostasis is also present in mature MIPKO and old Wt mice, suggesting a putative role of MIP in the decline of muscle function during aging. Our studies offer a new avenue for the investigation of MIP roles in skeletal muscle function and as a potential therapeutic target to treat aging sarcopenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.