ArticleNucleic acids research2011
BRCC36A is epistatic to BRCA1 in DNA crosslink repair and homologous recombination in Arabidopsis thaliana.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 41 citations in OpenAlex.
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- R-Loops in Genome Instability and Cancer.Cancers · 2023Review
- Chronic Ionizing Radiation of Plants: An Evolutionary Factor from Direct Damage to Non-Target Effects.Plants (Basel, Switzerland) · 2023Review
- Plant deubiquitinases: from structure and activity to biological functions.Plant cell reports · 2023Review
- Essential role of theBiotechnologia · 2023Article
- Long non-coding RNAs as the regulatory hubs in rice response to salt stress.Scientific reports · 2022Article
- Mapping of the plant SnRK1 kinase signalling network reveals a key regulatory role for the class II T6P synthase-like proteins.Nature plants · 2022Article
- Evolution of complex genome architecture in gymnosperms.GigaScience · 2022Article
- The DUB family in Populus: identification, characterization, evolution and expression patterns.BMC genomics · 2021Article
- The Dark Side of UV-Induced DNA Lesion Repair.Genes · 2020Review
- Review
- DNA- and DNA-Protein-Crosslink Repair in Plants.International journal of molecular sciences · 2019Review
- Identification of novel loci associated with maturity and yield traits in early maturity soybean plant introduction lines.BMC genomics · 2018Article
- Article
- Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones.Frontiers in plant science · 2017Review
- PEG Induces High Expression of the Cell Cycle Checkpoint GeneFrontiers in plant science · 2017Article
- Identification of Multiple Proteins Coupling Transcriptional Gene Silencing to Genome Stability in Arabidopsis thaliana.PLoS genetics · 2016Article
- Comparative Small RNA Analysis of Pollen Development in Autotetraploid and Diploid Rice.International journal of molecular sciences · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BRCA1 is a well-known tumor suppressor protein in mammals, involved in multiple cellular processes such as DNA repair, chromosome segregation and chromatin remodeling. Interestingly, homologs of BRCA1 and several of its complex partners are also found in plants. As the respective mutants are viable, in contrast to mammalian mutants, detailed analyses of their biological role is possible. Here we demonstrate that the model plant Arabidopsis thaliana harbors two homologs of the mammalian BRCA1 interaction partner BRCC36, AtBRCC36A and AtBRCC36B. Mutants of both genes as well as the double mutants are fully fertile and show no defects in development. We were able to show that mutation of one of the homologs, AtBRCC36A, leads to a severe defect in intra- and interchromosomal homologous recombination (HR). A HR defect is also apparent in Atbrca1 mutants. As the Atbrcc36a/Atbrca1 double mutant behaves like the single mutants of AtBRCA1 and AtBRCC36A both proteins seem to be involved in a common pathway in the regulation of HR. AtBRCC36 is also epistatic to AtBRCA1 in DNA crosslink repair. Upon genotoxic stress, AtBRCC36A is transferred into the nucleus.
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