ArticleAmerican journal of physiology. Heart and circulatory physiology2010
Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress.
Article in American journal of physiology. Heart and circulatory physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 87 citations in OpenAlex.
- Association of Cystathionine β-Synthase Gene Polymorphisms With Preeclampsia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- Phytoestrogen α-Zearalanol attenuates homocysteine-induced apoptosis in human umbilical vein endothelial cells.BioMed research international · 2013Trial
- Review
- Transsulfuration Pathway Products and HInternational journal of molecular sciences · 2025Review
- Chemistry of Hydrogen Sulfide-Pathological and Physiological Functions in Mammalian Cells.Cells · 2023Review
- Sulfur-Element containing metabolic pathways in human health and crosstalk with the microbiome.Biochemistry and biophysics reports · 2023Review
- Review
- IFC-305 attenuates renal ischemia-reperfusion injury by promoting the production of hydrogen sulfide (HBioengineered · 2022Article
- A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism.Antioxidants (Basel, Switzerland) · 2021Review
- Suppression of mitochondrial respiration by hydrogen sulfide in hibernating 13-lined ground squirrels.Free radical biology & medicine · 2021Article
- Hydrogen sulphide reduces hyperhomocysteinaemia-induced endothelial ER stress by sulfhydrating protein disulphide isomerase to attenuate atherosclerosis.Journal of cellular and molecular medicine · 2021Article
- Cysteine metabolic circuitries: druggable targets in cancer.British journal of cancer · 2021Review
- Morbidly obese subjects show increased serum sulfide in proportion to fat mass.International journal of obesity (2005) · 2021Article
- Protective Effects of Allicin on Acute Myocardial Infarction in RatsFrontiers in pharmacology · 2021Article
- The Torpid State: Recent Advances in Metabolic Adaptations and Protective MechanismsFrontiers in physiology · 2020Review
- Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance.British journal of cancer · 2020Article
- Hydrogen sulfide signaling in mitochondria and disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Review
- Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling.Comprehensive Physiology · 2019Review
- Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.Experimental eye research · 2019Article
- Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin BCommunications biology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Homocysteine, a cardiovascular and neurocognitive disease risk factor, is converted to hydrogen sulfide, a cardiovascular and neuronal protectant, through the transsulfuration pathway. Given the damaging effects of free homocysteine in the blood and the importance of blood homocysteine concentration as a prognosticator of disease, we tested the hypotheses that the blood itself regulates homocysteine-hydrogen sulfide metabolism through transsulfuration and that transsulfuration capacity and hydrogen sulfide availability protect the endothelium from redox stress. Here we show that the transsulfuration enzymes, cystathionine β-synthase and cystathionine γ-lyase, are secreted by microvascular endothelial cells and hepatocytes, circulate as members of the plasma proteome, and actively produce hydrogen sulfide from homocysteine in human blood. We further demonstrate that extracellular transsulfuration regulates cell function when the endothelium is challenged with homocysteine and that hydrogen sulfide protects the endothelium from serum starvation and from hypoxia-reoxygenation injury. These novel findings uncover a unique set of opportunities to explore innovative clinical diagnostics and therapeutic strategies in the approach to homocysteine-related conditions such as atherosclerosis, thrombosis, and dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.