ArticlePlant physiology2010
Microsatellite instability in Arabidopsis increases with plant development.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 79 citations in OpenAlex.
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- The Potential Role of Genic-SSRs in Driving Ecological Adaptation Diversity inInternational journal of molecular sciences · 2024Article
- Persistence of parental age effect on somatic mutation rates across generations in Arabidopsis.BMC plant biology · 2023Article
- Somatic Mutations in Fruit Trees: Causes, Detection Methods, and Molecular Mechanisms.Plants (Basel, Switzerland) · 2023Review
- Genome-Wide Survey and Development of the First Microsatellite Markers Database (International journal of molecular sciences · 2022Article
- Primary metabolic processes as drivers of leaf ageing.Cellular and molecular life sciences : CMLS · 2021Review
- A highly mutable GST is essential for bract colouration in Euphorbia pulcherrima Willd. Ex Klotsch.BMC genomics · 2021Article
- Genome-Wide Analysis of Simple Sequence Repeats in Cabbage (Frontiers in plant science · 2021Article
- Thermal stress acceleratesGenome research · 2021Article
- Application of genome-wide insertion/deletion markers on genetic structure analysis and identity signature of Malus accessions.BMC plant biology · 2020Article
- Attention sports fans! The far-reaching contributions of bud sport mutants to horticulture and plant biology.Horticulture research · 2018Article
- Comprehensive Characterization of Simple Sequence Repeats in Eggplant (Frontiers in plant science · 2018Article
- Arabidopsis thaliana siRNA biogenesis mutants have the lower frequency of homologous recombination.Plant signaling & behavior · 2016Article
- Suppression of the D-class MADS-box AGL11 gene triggers seedlessness in fleshy fruits.Plant cell reports · 2016Article
- A Genome-Wide Survey of the Microsatellite Content of the Globe Artichoke Genome and the Development of a Web-Based Database.PloS one · 2016Article
- Suppression of different classes of somatic mutations in Arabidopsis by vir gene-expressing Agrobacterium strains.BMC plant biology · 2015Article
- Parental age affects somatic mutation rates in the progeny of flowering plants.Plant physiology · 2015Article
- MIPSTR: a method for multiplex genotyping of germline and somatic STR variation across many individuals.Genome research · 2015Article
- DNA damage and repair in plants - from models to crops.Frontiers in plant science · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant development consists of the initial phase of intensive cell division followed by continuous genome endoreduplication, cell growth, and elongation. The maintenance of genome stability under these conditions is the main task performed by DNA repair and genome surveillance mechanisms. Our previous work showed that the rate of homologous recombination repair in older plants decreases. We hypothesized that this age-dependent decrease in the recombination rate is paralleled with other changes in DNA repair capacity. Here, we analyzed microsatellite stability using transgenic Arabidopsis (Arabidopsis thaliana) plants that carry the nonfunctional β-glucuronidase gene disrupted by microsatellite repeats. We found that microsatellite instability increased dramatically with plant age. We analyzed the contribution of various mechanisms to microsatellite instability, including replication errors and mistakes of DNA repair mechanisms such as mismatch repair, excision repair, and strand break repair. Analysis of total DNA polymerase activity using partially purified protein extracts showed an age-dependent decrease in activity and an increase in fidelity. Analysis of the steady-state RNA level of DNA replicative polymerases α, δ, Pol I-like A, and Pol I-like B and the expression of mutS homolog 2 (Msh2) and Msh6 showed an age-dependent decrease. An in vitro repair assay showed lower efficiency of nonhomologous end joining in older plants, paralleled by an increase in Ku70 gene expression. Thus, we assume that the more frequent involvement of nonhomologous end joining in strand break repair and the less efficient end-joining repair together with lower levels of mismatch repair activities may be the main contributors to the observed age-dependent increase in microsatellite instability.
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