ArticleNucleic acids research2011
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 157 citations in OpenAlex.
- Structural basis for transcriptional regulation by the cell division regulator MraZ in Mycoplasma genitalium.Nature communications · 2026Article
- Transcription regulator TrtA modulates oxygen stress response inApplied and environmental microbiology · 2025Article
- A quorum sensing-controlled type I CRISPRi toolkit for dynamically regulating metabolic flux.Nucleic acids research · 2025Article
- The iron chelator pulcherriminic acid mediates the light response in Bacillus subtilis biofilms.Nature communications · 2025Article
- Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis.FEBS letters · 2025Article
- The role of AbrB from plate to bioreactor: implications of induced expression on physiological and metabolic responses in Bacillus thuringiensis.World journal of microbiology & biotechnology · 2025Article
- Differential expression of theApplied and environmental microbiology · 2024Article
- Understanding energy fluctuation during the transition state: The role of AbrB in Bacillus licheniformis.Microbial cell factories · 2024Article
- Anaerobic benzene oxidation inApplied and environmental microbiology · 2024Article
- The characteristics of autolysins associated with cell separation inJournal of bacteriology · 2024Article
- An Integrated Pipeline and Overexpression of a Novel Efflux Transporter, YoeA, Significantly Increases Plipastatin Production inFoods (Basel, Switzerland) · 2024Article
- Two distinct regulatory systems control pulcherrimin biosynthesis in Bacillus subtilis.PLoS genetics · 2024Article
- Research advances in the identification of regulatory mechanisms of surfactin production by Bacillus: a review.Microbial cell factories · 2024Review
- Abh, AbrB3, and Spo0A play distinct regulatory roles during polymyxin synthesis inMicrobiology spectrum · 2024Article
- Two Distinct Regulatory Systems Control Pulcherrimin Biosynthesis inbioRxiv : the preprint server for biology · 2024Article
- GeF-seq: A Simple Procedure for Base-Pair Resolution ChIP-seq.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The alternative sigma factor SigN ofJournal of bacteriology · 2023Article
- A review on surfactin: molecular regulation of biosynthesis.Archives of microbiology · 2023Review
- Termination factor Rho mediates transcriptional reprogramming of Bacillus subtilis stationary phase.PLoS genetics · 2023Article
- Transcriptomic Analysis Reveals the Role of tmRNA on Biofilm Formation inMicroorganisms · 2022Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AbrB is a global transcriptional regulator of Bacillus subtilis that represses the expression of many genes during exponential growth. Here, we demonstrate that AbrB and its homolog Abh bind to hundreds of sites throughout the entire B. subtilis genome during exponential growth. Comparison of regional binding of AbrB and Abh in wild-type, ΔabrB and Δabh backgrounds revealed that they bind as homomer and/or heteromer forms with different specificities and affinities. We found four AbrB and Abh binding patterns were major. Three of these contain pairs of TGGNA motifs connected by A/T-rich sequences, differing in arrangement and spacing. We also assessed the direct involvement of these complexes in the control of gene expression. Our data indicate that AbrB usually acts as a repressor, and that the ability of Abh to act as a transcriptional regulator was limited. We found that changes to AbrB/Abh levels affect their binding at several promoters and consequently transcriptional regulation. Surprisingly, most AbrB/Abh binding events had no impact on transcription, suggesting an interesting possibility that AbrB/Abh binding is analogous to nucleoid-associated protein binding in Escherichia coli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.