ArticleJournal of the American Society for Mass Spectrometry2010
The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles.
Article in Journal of the American Society for Mass Spectrometry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 73 citations in OpenAlex.
- Recent progress in nanomaterial-enhanced SALDI-MSI for spatial metabolomics.Analytical and bioanalytical chemistry · 2026Review
- MALDI Matrix: Origins, Innovations, and Frontiers.Chemical reviews · 2026Review
- Deciphering mouse brain spatial diversity via glyco-lipidomic mapping.Nature communications · 2024Article
- Development of a Mass Spectrometry Imaging Method to Evaluate the Penetration of Moisturizing Components Coated on Surgical Gloves into Artificial Membranes.Mass spectrometry (Tokyo, Japan) · 2024Article
- Surface-assisted laser desorption/ionization mass spectrometry imaging: A review.Mass spectrometry reviews · 2022Review
- Dual-polarity SALDI FT-ICR MS imaging and Kendrick mass defect data filtering for lipid analysis.Analytical and bioanalytical chemistry · 2021Article
- Organic matrix-free imaging mass spectrometry.BMB reports · 2020Review
- Assessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications.PloS one · 2018Article
- Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles.Journal of the American Society for Mass Spectrometry · 2017Article
- Inflation-Fixation Method for Lipidomic Mapping of Lung Biopsies by Matrix Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging.Analytical chemistry · 2016Article
- Article
- Analysis of the lipidome of xenografts using MALDI-IMS and UHPLC-ESI-QTOF.Journal of the American Society for Mass Spectrometry · 2014Article
- Imaging of lipids in rat heart by MALDI-MS with silver nanoparticles.Analytical and bioanalytical chemistry · 2014Article
- Mass spectrometry imaging, an emerging technology in neuropsychopharmacology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Review
- Current status and future perspectives of mass spectrometry imaging.International journal of molecular sciences · 2013Review
- Differential distribution of major brain gangliosides in the adult mouse central nervous system.PloS one · 2013Article
- Mass spectrometry imaging and profiling of single cells.Journal of proteomics · 2012Review
- Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Chemical reviews · 2011Review
- Molecular Microscopy of Brain Gangliosides: Illustrating their Distribution in Hippocampal Cell Layers.ACS chemical neuroscience · 2011Article
- Investigation by imaging mass spectrometry of biomarker candidates for aging in the hair cortex.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycosphingolipids (GSLs) are amphiphilic molecules consisting of a hydrophilic carbohydrate chain and a hydrophobic ceramide moiety. They appear to be involved primarily in biological processes such as cell proliferation, differentiation, and signaling. To investigate the mechanism of brain function in more detail, a more highly sensitive method that would reveal the GSL distribution in the brain is required. In this report, we describe a simple and efficient method for mapping the distribution and localization of GSLs present in mouse brain sections using nanoparticle-assisted laser desorption/ionization imaging mass spectrometry (IMS). We have developed and tested gold nanoparticles (AuNPs) as a new matrix to maximize the detection of GSLs. A matrix of AuNPs modified with alkylamine was used to detect various GSLs, such as minor molecular species of sulfatides and gangliosides, in mouse brain sections; these GSLs were hardly detected using 2,5-dihydroxybenzoic acid (DHB), which is the conventional matrix for GSLs. We achieved approximately 20 times more sensitive detection of GSLs using AuNPs compared to a DHB matrix. We believe that our new approach using AuNPs in IMS could lead to a new strategy for analyzing basic biological mechanisms and several diseases through the distribution of minor GSLs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.