ArticleAmerican journal of human genetics2010
Mutability of Y-chromosomal microsatellites: rates, characteristics, molecular bases, and forensic implications.
Article in American journal of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.
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Who cites it
144 citing papers in PubMed.
- Assessing 23 Y-STR loci mutation rates in Chinese Han father-son pairs from southwestern China.Molecular biology reports · 2020Trial
- Decoding paternal genetic architecture of Gujarati Brahmin population of India using 27 Y-STRs: Diversity, structure, and global comparison.International journal of legal medicine · 2026Article
- Forensic validation and population genetic evaluation of an MPS-based integrated microhaplotype and Y-SNP/STR (MY) system.Biochemistry and biophysics reports · 2026Article
- A high-resolution Y-chromosomal panel for forensic paternal lineage tracing and anthropological insight: unraveling the genetic structure of the Dongxiang ethnic minority.International journal of legal medicine · 2026Article
- The Genetic Structure of the Romanian Male Population Revealed by 27 Y-Chromosome STR Loci.International journal of molecular sciences · 2026Article
- Article
- Large-scale human genomic resources drive innovations toward forensic intelligent source attribution and precision identification.International journal of legal medicine · 2026Review
- DNA Mixture Deconvolution: A Four-Strategy Framework from Physical Separation to Database Searching.Genes · 2026Review
- The Contribution of Massively Parallel Sequencing in Disclosing Unusual Tri- and Tetra-Allelic Type Patterns Detected at the Multicopy Loci DYS385a/b and DYF387S1.International journal of molecular sciences · 2026Article
- Genetic characterization of the Bai population from Yunnan province in China based on Y-STR population data.Forensic science, medicine, and pathology · 2026Article
- Forensic applications of rapidly mutating Y-STR markers: current status and future perspectives.Forensic science, medicine, and pathology · 2026Review
- Forensic genetics in the omics era.Nature reviews. Genetics · 2026Review
- Genome-wide selection inference at short tandem repeats.PLoS genetics · 2025Article
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- Article
- Detection of sequence-tagged sites to reveal mechanisms of multi-step mutations at multi-copy Y-STRs in father-son pairs.International journal of legal medicine · 2025Article
- Article
- Analysis of the mutation rates and male relative differentiation ability of RM Y-STRs in the Chinese Han population.Scientific reports · 2025Article
- A novel mathematical framework for pedigree-based calculation of Y-STR match probabilities.Scientific reports · 2025Article
- Genomic insights into Neolithic founding paternal lineages around the Qinghai-Xizang Plateau using integrated YanHuang resource.iScience · 2024Article
84 more citing papers are in PubMed but not listed here.
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25 authors.
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Abstract
Nonrecombining Y-chromosomal microsatellites (Y-STRs) are widely used to infer population histories, discover genealogical relationships, and identify males for criminal justice purposes. Although a key requirement for their application is reliable mutability knowledge, empirical data are only available for a small number of Y-STRs thus far. To rectify this, we analyzed a large number of 186 Y-STR markers in nearly 2000 DNA-confirmed father-son pairs, covering an overall number of 352,999 meiotic transfers. Following confirmation by DNA sequence analysis, the retrieved mutation data were modeled via a Bayesian approach, resulting in mutation rates from 3.78 × 10(-4) (95% credible interval [CI], 1.38 × 10(-5) - 2.02 × 10(-3)) to 7.44 × 10(-2) (95% CI, 6.51 × 10(-2) - 9.09 × 10(-2)) per marker per generation. With the 924 mutations at 120 Y-STR markers, a nonsignificant excess of repeat losses versus gains (1.16:1), as well as a strong and significant excess of single-repeat versus multirepeat changes (25.23:1), was observed. Although the total repeat number influenced Y-STR locus mutability most strongly, repeat complexity, the length in base pairs of the repeated motif, and the father's age also contributed to Y-STR mutability. To exemplify how to practically utilize this knowledge, we analyzed the 13 most mutable Y-STRs in an independent sample set and empirically proved their suitability for distinguishing close and distantly related males. This finding is expected to revolutionize Y-chromosomal applications in forensic biology, from previous male lineage differentiation toward future male individual identification.
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