ArticlePeptides2010
Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats.
Article in Peptides, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Intracerebroventricular administration of TRH Agonist, RX-77368 alleviates visceral pain induced by colorectal distension in rats.Peptides · 2024Article
- Article
- Gut-Brain Neuroendocrine Signaling Under Conditions of Stress-Focus on Food Intake-Regulatory Mediators.Frontiers in endocrinology · 2018Review
- Abdominal surgery induced gastric ileus and activation of M1-like macrophages in the gastric myenteric plexus: prevention by central vagal activation in rats.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.The Journal of clinical investigation · 2016Article
- A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood.Journal of visualized experiments : JoVE · 2016Article
- Ghrelin enhancer, rikkunshito, improves postprandial gastric motor dysfunction in an experimental stress model.Neurogastroenterology and motility · 2015Article
- The influence of environmental temperature on appetite-related hormonal responses.Journal of physiological anthropology · 2015Article
- A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Brain peptides and the modulation of postoperative gastric ileus.Current opinion in pharmacology · 2014Review
- Peripheral α2-β1 adrenergic interactions mediate the ghrelin response to brain urocortin 1 in rats.Psychoneuroendocrinology · 2014Article
- Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted rats.Neurogastroenterology and motility · 2012Article
- Yin and Yang - the Gastric X/A-like Cell as Possible Dual Regulator of Food Intake.Journal of neurogastroenterology and motility · 2012Article
- Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications.Frontiers in endocrinology · 2012Article
- Ghrelin - a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach.Frontiers in neuroscience · 2012Article
- Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents.Current medicinal chemistry · 2012Review
- Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implications.Peptides · 2011Review
- Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Central administration of pan-somatostatin agonist ODT8-SST prevents abdominal surgery-induced inhibition of circulating ghrelin, food intake and gastric emptying in rats.Neurogastroenterology and motility · 2011Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated whether acute cold-induced vagal activation through brainstem thyrotropin-releasing hormone (TRH) signaling influences abdominal surgery-induced delayed gastric emptying (GE) in fasted rats. Laparotomy and cecal palpation or sham (short anesthesia alone) was performed 10 min before or 30 min after cold exposure (4-6°C) lasting 90 min. Non-nutrient GE was assessed during 70-90 min of cold exposure. Control groups remained at room temperature (RT). The stable TRH analog, RX-77368 (50 ng/rat) was injected intracisternally immediately before surgery and GE monitored 30-50 min postsurgery in rats maintained at RT. Plasma acyl (AG) and total ghrelin levels were assessed using the new RAPID blood processing method and radioimmunoassays. Desacyl ghrelin (DAG) was derived from total minus AG. In rats maintained at RT, abdominal surgery decreased GE by 60% compared to sham. Cold before or after surgery or RX-77368 normalized the delayed GE. In non-fasted rats, cold exposure increased plasma AG and DAG levels at 2 h (2.4- and 2.7-times, respectively) and 4 h (2.2- and 2.0-times, respectively) compared to values in rats maintained at RT. In fasted rats, abdominal surgery decreased AG and DAG levels by 2.4- and 2.1-times, respectively, at 90 min. Cold for 90 min after surgery normalized AG and DAG levels to those observed in sham-treated animals kept at RT. These data indicate that endogenous (cold exposure) and exogenous (TRH analog) activation of medullary TRH vagal signaling prevent abdominal surgery-induced delayed GE. The restoration of circulating AG levels inhibited by abdominal surgery may contribute to alleviate postoperative gastric ileus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.