ArticleBehavioural brain research2011
The effects of pre-pubertal gonadectomy and binge-like ethanol exposure during adolescence on ethanol drinking in adult male and female rats.
Article in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Sex hormones in alcohol consumption: a systematic review of evidence.Addiction biology · 2019Pooled it
- Neurotoxic biomarkers of ethanol exposure: from adolescent vulnerability to adult voluntary intake in rats of both sexes.The international journal of neuropsychopharmacology · 2025Article
- Cannabidiol or ketamine for preventing the impact of adolescent early drug initiation on voluntary ethanol consumption in adulthood.Frontiers in pharmacology · 2024Article
- Reward maximization assessed using a sequential patch depletion task in a large sample of heterogeneous stock rats.Scientific reports · 2023Article
- Sex differences in sucrose reinforcement in Long-Evans rats.Biology of sex differences · 2022Article
- Moderate Adolescent Ethanol Vapor Exposure and Acute Stress in Adulthood: Sex-Dependent Effects on Social Behavior and Ethanol Intake in Sprague-Dawley Rats.Brain sciences · 2020Article
- Gonadal hormones affect alcohol drinking, but not cue+yohimbine-induced alcohol seeking, in male and female rats.Physiology & behavior · 2019Article
- Sexual dimorphism in the neural impact of stress and alcohol.Alcohol (Fayetteville, N.Y.) · 2018Review
- Sex differences in adolescent ethanol drinking to behavioral intoxication.Journal of the experimental analysis of behavior · 2018Article
- Chronic Intermittent Ethanol Exposure Modulation of Glutamatergic Neurotransmission in Rat Lateral/Basolateral Amygdala is Duration-, Input-, and Sex-Dependent.Neuroscience · 2018Article
- Nicotine Increases Alcohol Intake in Adolescent Male Rats.Frontiers in behavioral neuroscience · 2017Article
- Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?Brain research · 2017Review
- Sex differences in behavior and neural development and their role in adolescent vulnerability to substance use.Behavioural brain research · 2016Review
- Emergence of sex differences in the development of substance use and abuse during adolescence.Pharmacology & therapeutics · 2015Review
- Sex differences in the long-lasting consequences of adolescent ethanol exposure for the rewarding effects of cocaine in mice.Psychopharmacology · 2015Article
- Gonadectomy before puberty increases the number of neurons and glia in the medial prefrontal cortex of female, but not male, rats.Developmental psychobiology · 2015Article
- Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction.Neuroscience · 2014Review
- Pre-pubertal gonadectomy and the social consequences of acute ethanol in adolescent male and female rats.Hormones and behavior · 2014Article
- Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Article
- Age and sex differences in reward behavior in adolescent and adult rats.Developmental psychobiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The pubertal surge in gonadal hormones that occurs during adolescence may impact the long-term effects of early alcohol exposure and sex differences in drinking behavior in adulthood. We investigated this hypothesis by performing sham or gonadectomy surgeries in Long-Evans rats around post-natal day (P) 20. From P35-45, males and females were given saline or 3.0 g/kg ethanol using a binge-like model of exposure (8 injections total). As adults (P100), they were trained to self-administer ethanol via a sucrose-fading procedure and then given access to different unsweetened concentrations (5-20%, w/v) for 5 days/concentration. We found that during adolescence, ethanol-induced intoxication was similar in males and females that underwent sham surgery. In gonadectomized males and females, however, the level of intoxication was greater following the last injection compared to the first. During adulthood, females drank more sucrose per body weight than males and binge-like exposure to ethanol reduced sucrose consumption in both sexes. These effects were not seen in gonadectomized rats. Ethanol consumption was higher in saline-exposed females compared to males, with gonadectomy reversing this sex difference by increasing consumption in males and decreasing it in females. Exposure to ethanol during adolescence augmented ethanol consumption in both sexes, but this effect was statistically significant only in gonadectomized females. Together, these results support a role for gonadal hormones during puberty in the short- and long-term effects of ethanol on behavior and in the development of sex differences in consummatory behavior during adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.