ArticleHearing research2011
Dynamic modulation of short-term synaptic plasticity in the auditory cortex: the role of norepinephrine.
Article in Hearing research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Interleaving asynchronous and synchronous activity in balanced cortical networks with short term synaptic depression.Nature communications · 2025Article
- Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine.Frontiers in cellular neuroscience · 2025Article
- Incorporating behavioral and sensory context into spectro-temporal models of auditory encoding.Hearing research · 2018Review
- Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats.Frontiers in neural circuits · 2016Article
- Norepinephrine Modulates Coding of Complex Vocalizations in the Songbird Auditory Cortex Independent of Local Neuroestrogen Synthesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Stimulus-specific effects of noradrenaline in auditory cortex: implications for the discrimination of communication sounds.The Journal of physiology · 2015Article
- β-Adrenoceptors and synaptic plasticity in the perirhinal cortex.Neuroscience · 2014Article
- Inhibitory glycinergic neurotransmission in the mammalian auditory brainstem upon prolonged stimulation: short-term plasticity and synaptic reliability.Frontiers in neural circuits · 2014Article
- Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism.The international journal of neuropsychopharmacology · 2013Article
- Auditory map reorganization and pitch discrimination in adult rats chronically exposed to low-level ambient noise.Frontiers in systems neuroscience · 2012Article
- Synaptic short-term plasticity in auditory cortical circuits.Hearing research · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Norepinephrine (NE) is an important modulator of neuronal activity in the auditory cortex. Using patch-clamp recording and a pair pulse protocol on an auditory cortex slice preparation we recently demonstrated that NE affects cortical inhibition in a layer-specific manner, by decreasing apical but increasing basal inhibition onto layer II/III pyramidal cell dendrites. In the present study we used a similar protocol to investigate the dependence of noradrenergic modulation of inhibition on stimulus frequency, using 1s-long train pulses at 5, 10, and 20 Hz. The study was conducted using pharmacologically isolated inhibitory postsynaptic currents (IPSCs) evoked by electrical stimulation of axons either in layer I (LI-eIPSCs) or in layer II/III (LII/III-eIPSCs). We found that: 1) LI-eIPSC display less synaptic depression than LII/III-eIPSCs at all the frequencies tested, 2) in both type of synapses depression had a presynaptic component which could be altered manipulating [Ca²+]₀, 3) NE modestly altered short-term synaptic plasticity at low or intermediate (5-10 Hz) frequencies, but selectively enhanced synaptic facilitation in LI-eIPSCs while increasing synaptic depression of LII/III-eIPSCs in the latest (>250 ms) part of the response, at high stimulation frequency (20 Hz). We speculate that these mechanisms may limit the temporal window for top-down synaptic integration as well as the duration and intensity of stimulus-evoked gamma-oscillations triggered by complex auditory stimuli during alertness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.