Evidence map›Paper›PMID 20816393›Full record

ReviewCurrent topics in developmental biology2010

Canonical and non-canonical Notch ligands.

Brendan D'Souza, Laurence Meloty-Kapella, Gerry Weinmaster

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current topics in developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brendan D'SouzaDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Laurence Meloty-Kapella
Gerry Weinmaster

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Notch Signaling in Mammalian CellsR37NS031885 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEINMASTER, GERALDINE A · 2003 to 2009
$2.6M
DSL ligand endocytosis in Notch activationR01GM085032 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEINMASTER, GERALDINE A · 2011 to 2014
$1.2M
NOTCH SIGNALING IN MAMMALIAN CELLSR01NS031885 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEINMASTER, GERALDINE A · 1994 to 2002
$799k
NIGMS NIH HHS R01 GM085032NIGMS NIH HHS T32 GM007185NINDS NIH HHS R01 NS031885NINDS NIH HHS R37 NS031885
6 · The paper itself

Abstract

Notch signaling induced by canonical Notch ligands is critical for normal embryonic development and tissue homeostasis through the regulation of a variety of cell fate decisions and cellular processes. Activation of Notch signaling is normally tightly controlled by direct interactions with ligand-expressing cells, and dysregulated Notch signaling is associated with developmental abnormalities and cancer. While canonical Notch ligands are responsible for the majority of Notch signaling, a diverse group of structurally unrelated noncanonical ligands has also been identified that activate Notch and likely contribute to the pleiotropic effects of Notch signaling. Soluble forms of both canonical and noncanonical ligands have been isolated, some of which block Notch signaling and could serve as natural inhibitors of this pathway. Ligand activity can also be indirectly regulated by other signaling pathways at the level of ligand expression, serving to spatiotemporally compartmentalize Notch signaling activity and integrate Notch signaling into a molecular network that orchestrates developmental events. Here, we review the molecular mechanisms underlying the dual role of Notch ligands as activators and inhibitors of Notch signaling. Additionally, evidence that Notch ligands function independent of Notch is presented. We also discuss how ligand posttranslational modification, endocytosis, proteolysis, and spatiotemporal expression regulate their signaling activity.

Indexed as

Protein Processing, Post-TranslationalSignal TransductionAnimalsHumansLigandsReceptors, NotchLigandsReceptors, Notch

Identifiers

PMID20816393
PMCPMC4286395

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.