ArticleAmerican journal of obstetrics and gynecology2010
Obesity and diabetes genetic variants associated with gestational weight gain.
Article in American journal of obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- Pooled it
- Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.PloS one · 2012Pooled it
- Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women.Nutrition (Burbank, Los Angeles County, Calif.) · 2018Trial
- Genetic and epigenetic alterations associated with gestational diabetes mellitus and adverse neonatal outcomes.World journal of clinical pediatrics · 2025Review
- Association betweenFrontiers in endocrinology · 2025Article
- Genomic Insights into Gestational Weight Gain: Uncovering Tissue-Specific Mechanisms and Pathways.Research square · 2024Article
- Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review.International journal of molecular sciences · 2024Review
- Genomic insights into gestational weight gain uncover tissue-specific mechanisms and pathways.npj women's health · 2024Article
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- TMT-based proteomic and bioinformatic analyses of human granulosa cells from obese and normal-weight female subjects.Reproductive biology and endocrinology : RB&E · 2021Article
- Maternal and Offspring Genetic Risk of Type 2 Diabetes and Offspring Birthweight Among African Ancestry Populations.The Journal of clinical endocrinology and metabolism · 2019Article
- Heterogeneous impact of type 2 diabetes mellitus-related genetic variants on gestational glycemic traits: review and future research needs.Molecular genetics and genomics : MGG · 2019Review
- Variants in BMI-Associated Genes and Adrenergic Genes are not Associated with Gestational Weight Trajectory.Obesity (Silver Spring, Md.) · 2019Article
- Maternal genetic contribution to pre-pregnancy obesity, gestational weight gain, and gestational diabetes mellitus.Diabetology & metabolic syndrome · 2019Article
- Maternal and fetal genetic contribution to gestational weight gain.International journal of obesity (2005) · 2018Article
- An Exploration of the Determinants of Gestational Weight Gain in African American Women: Genetic Factors and Energy Expenditure.Biological research for nursing · 2018Observational
- The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women.Journal of nutrition and metabolism · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain. STUDY
designA total of 960 participants in the Pregnancy, Infection, and Nutrition cohorts were genotyped for 27 single-nucleotide polymorphisms (SNPs) associated with diabetes and obesity.
resultsAmong Caucasian and African American women (n = 960), KCNQ1 risk allele carriage was directly associated with weight gain (P < .01). In Bayesian hierarchical models among Caucasian women (n = 628), we found posterior odds ratios >3 for inclusion of TCF2 and THADA SNPs in our models. Among African American women (n = 332), we found associations between risk allele carriage and weight gain for the THADA and INSIG2 SNPs. In Bayesian variable selection models, we found an interaction between the TSPAN8 risk allele and pregravid obesity, with lower weight gain among obese risk allele carriers.
conclusionWe found evidence that diabetes and obesity risk alleles interact with maternal pregravid body mass index to predict gestational weight gain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.