ArticleAmerican journal of obstetrics and gynecology2010
Betamethasone in pregnancy: influence of maternal body weight and multiple gestation on pharmacokinetics.
Article in American journal of obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Mechanistic Prediction of Maternal, Fetal, and Amniotic Fluid Betamethasone Concentrations to Support Dosing Optimization in Pregnancy.Journal of clinical pharmacology · 2026Article
- Placenta-pulmonary coupling-guided multimodal AI for fetal lung maturity staging and individualized glucocorticoid therapy.Frontiers in medicine · 2026Article
- Pharmacokinetics of betamethasone in pre-eclampsia: An in vivo and ex vivo study.British journal of clinical pharmacology · 2025Article
- Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy.BMC medicine · 2025Article
- The role of antenatal corticosteroids in twin pregnancy.Frontiers in pharmacology · 2023Review
- The Effect of Pregnancy and Inflammatory Bowel Disease on the Pharmacokinetics of Drugs Related to Inflammatory Bowel Disease-A Systematic Literature Review.Pharmaceutics · 2022Review
- Do maternal demographics and prenatal history impact the efficacy of betamethasone therapy for threatened preterm labor?BMC pregnancy and childbirth · 2021Article
- Glucocorticoids, sodium transport mediators, and respiratory distress syndrome in preterm infants.Pediatric research · 2021Article
- Drug dosing during pregnancy-opportunities for physiologically based pharmacokinetic models.Journal of pharmacokinetics and pharmacodynamics · 2020Review
- Optimizing antenatal corticosteroid therapy for improving outcome of premature infants.Pediatric research · 2019Article
- Impact of antenatal corticosteroids in preterm neonates based on maternal body mass index.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Minireview: the impact of antenatal therapeutic synthetic glucocorticoids on the developing fetal brain.Molecular endocrinology (Baltimore, Md.) · 2015Review
- Influence of gestational age and body weight on the pharmacokinetics of labetalol in pregnancy.Clinical pharmacokinetics · 2014Article
- Article
- Maternal hepatic growth response to pregnancy in the mouse.Experimental biology and medicine (Maywood, N.J.) · 2011Article
- Judicious use of antenatal glucocorticoids: putting the risks into the balance.Facts, views & vision in ObGyn · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe goals of the study were to estimate the pharmacokinetic parameters of standard dose betamethasone in a large obstetrics population and evaluate the effect of maternal body size and multiple gestation on the pharmacokinetic parameters and their observed variability. STUDY
designThis was a prospective pharmacokinetic study. Liquid chromatography mass spectrometry was used to measure betamethasone plasma concentrations. Pharmacokinetic parameters and significant clinical covariates were estimated with mixed effect modeling. Bootstrap analysis confirmed validity of the model.
resultsTwo hundred seventy-four blood samples from 77 patients were obtained. The greatest effect on pharmacokinetic variability was observed with maternal lean body weight (LBW). The relationship between the pharmacokinetic parameters and LBW remained linear over a wide range of maternal body sizes. Multiple gestations did not affect the pharmacokinetic parameters.
conclusionIndividualization of betamethasone dosing by maternal LBW reduces variability in drug exposure. Mutiple gestations do not require betamethasone dosing adjustment, because pharmacokinetics are the same as singleton gestations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.